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Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia

Treatment of the central nervous system (CNS) is an essential therapeutic component in childhood acute lymphoblastic leukemia (ALL). The goal of this study was to identify molecular signatures distinguishing patients with CNS disease from those without the disease in pediatric patients with ALL. We...

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Autores principales: Hicks, Chindo, Sitthi-Amorn, Jitsuda, Douglas, Jessica, Ramani, Ritika, Miele, Lucio, Vijayakumar, Vani, Karlson, Cynthia, Chipeta, James, Megason, Gail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792199/
https://www.ncbi.nlm.nih.gov/pubmed/26997880
http://dx.doi.org/10.4137/CMO.S18180
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author Hicks, Chindo
Sitthi-Amorn, Jitsuda
Douglas, Jessica
Ramani, Ritika
Miele, Lucio
Vijayakumar, Vani
Karlson, Cynthia
Chipeta, James
Megason, Gail
author_facet Hicks, Chindo
Sitthi-Amorn, Jitsuda
Douglas, Jessica
Ramani, Ritika
Miele, Lucio
Vijayakumar, Vani
Karlson, Cynthia
Chipeta, James
Megason, Gail
author_sort Hicks, Chindo
collection PubMed
description Treatment of the central nervous system (CNS) is an essential therapeutic component in childhood acute lymphoblastic leukemia (ALL). The goal of this study was to identify molecular signatures distinguishing patients with CNS disease from those without the disease in pediatric patients with ALL. We analyzed gene expression data from 207 pediatric patients with ALL. Patients without CNS were classified as CNS1, while those with mild and advanced CNS disease were classified as CNS2 and CNS3, respectively. We compared gene expression levels among the three disease classes. We identified gene signatures distinguishing the three disease classes. Pathway analysis revealed molecular networks and biological pathways dysregulated in response to CNS disease involvement. The identified pathways included the ILK, WNT, B-cell receptor, AMPK, ERK5, and JAK signaling pathways. The results demonstrate that transcription profiling could be used to stratify patients to guide therapeutic decision-making in pediatric ALL.
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spelling pubmed-47921992016-03-19 Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia Hicks, Chindo Sitthi-Amorn, Jitsuda Douglas, Jessica Ramani, Ritika Miele, Lucio Vijayakumar, Vani Karlson, Cynthia Chipeta, James Megason, Gail Clin Med Insights Oncol Original Research Treatment of the central nervous system (CNS) is an essential therapeutic component in childhood acute lymphoblastic leukemia (ALL). The goal of this study was to identify molecular signatures distinguishing patients with CNS disease from those without the disease in pediatric patients with ALL. We analyzed gene expression data from 207 pediatric patients with ALL. Patients without CNS were classified as CNS1, while those with mild and advanced CNS disease were classified as CNS2 and CNS3, respectively. We compared gene expression levels among the three disease classes. We identified gene signatures distinguishing the three disease classes. Pathway analysis revealed molecular networks and biological pathways dysregulated in response to CNS disease involvement. The identified pathways included the ILK, WNT, B-cell receptor, AMPK, ERK5, and JAK signaling pathways. The results demonstrate that transcription profiling could be used to stratify patients to guide therapeutic decision-making in pediatric ALL. Libertas Academica 2016-03-14 /pmc/articles/PMC4792199/ /pubmed/26997880 http://dx.doi.org/10.4137/CMO.S18180 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Hicks, Chindo
Sitthi-Amorn, Jitsuda
Douglas, Jessica
Ramani, Ritika
Miele, Lucio
Vijayakumar, Vani
Karlson, Cynthia
Chipeta, James
Megason, Gail
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title_full Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title_fullStr Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title_full_unstemmed Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title_short Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
title_sort molecular analysis of central nervous system disease spectrum in childhood acute lymphoblastic leukemia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792199/
https://www.ncbi.nlm.nih.gov/pubmed/26997880
http://dx.doi.org/10.4137/CMO.S18180
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