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Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder

Systemic lupus erythematosus (SLE) is an autoimmune disease in which cells and tissues undergo damage mediated by tissue-binding autoantibodies. At its onset, it may involve one organ alone or more than one organ simultaneously; over a time, additional manifestations due to the involvement of other...

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Autores principales: Arathi, N, Sasidharan, PK, Geetha, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792217/
https://www.ncbi.nlm.nih.gov/pubmed/27022308
http://dx.doi.org/10.2147/JBM.S95839
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author Arathi, N
Sasidharan, PK
Geetha, P
author_facet Arathi, N
Sasidharan, PK
Geetha, P
author_sort Arathi, N
collection PubMed
description Systemic lupus erythematosus (SLE) is an autoimmune disease in which cells and tissues undergo damage mediated by tissue-binding autoantibodies. At its onset, it may involve one organ alone or more than one organ simultaneously; over a time, additional manifestations due to the involvement of other organs may occur. Our observations have confirmed that hematological manifestations are the commonest initial presentation in SLE. The criteria used till 2012 was the American College of Rheumatology (ACR) criteria, which is only a classification criterion and not really for diagnosis; if we rely on ACR criteria, the diagnosis is often delayed. Time required for satisfying all four of the eleven criteria is variable and prolonged. Moreover, hematological manifestations are underrepresented in the ACR criteria. Based on the clinical observations made on patients evaluated in a tertiary center in North Kerala, an alternate diagnostic criterion named the Kozhikode criteria was proposed, especially for the diagnosis of SLE when it presents with hematological manifestations alone. The present study was an attempt to validate the same and to look for any association of diet and lifestyle with the disease.
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spelling pubmed-47922172016-03-28 Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder Arathi, N Sasidharan, PK Geetha, P J Blood Med Original Research Systemic lupus erythematosus (SLE) is an autoimmune disease in which cells and tissues undergo damage mediated by tissue-binding autoantibodies. At its onset, it may involve one organ alone or more than one organ simultaneously; over a time, additional manifestations due to the involvement of other organs may occur. Our observations have confirmed that hematological manifestations are the commonest initial presentation in SLE. The criteria used till 2012 was the American College of Rheumatology (ACR) criteria, which is only a classification criterion and not really for diagnosis; if we rely on ACR criteria, the diagnosis is often delayed. Time required for satisfying all four of the eleven criteria is variable and prolonged. Moreover, hematological manifestations are underrepresented in the ACR criteria. Based on the clinical observations made on patients evaluated in a tertiary center in North Kerala, an alternate diagnostic criterion named the Kozhikode criteria was proposed, especially for the diagnosis of SLE when it presents with hematological manifestations alone. The present study was an attempt to validate the same and to look for any association of diet and lifestyle with the disease. Dove Medical Press 2016-03-08 /pmc/articles/PMC4792217/ /pubmed/27022308 http://dx.doi.org/10.2147/JBM.S95839 Text en © 2016 Arathi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Arathi, N
Sasidharan, PK
Geetha, P
Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title_full Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title_fullStr Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title_full_unstemmed Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title_short Kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
title_sort kozhikode criteria for diagnosing systemic lupus erythematosus as a hematological disorder
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792217/
https://www.ncbi.nlm.nih.gov/pubmed/27022308
http://dx.doi.org/10.2147/JBM.S95839
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