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Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China

Toxoplasmosis, a neglected tropical disease caused by the protozoan parasite Toxoplasma gondii, occurs throughout the world. Human T. gondii infection is asymptomatic in 80% of the population; however, the infection is life-threatening and causes substantial neurologic damage in immunocompromised pa...

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Autores principales: Shen, Guoqiang, Wang, Xiaoming, Sun, Hui, Gao, Yaying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792320/
https://www.ncbi.nlm.nih.gov/pubmed/26951986
http://dx.doi.org/10.3347/kjp.2016.54.1.93
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author Shen, Guoqiang
Wang, Xiaoming
Sun, Hui
Gao, Yaying
author_facet Shen, Guoqiang
Wang, Xiaoming
Sun, Hui
Gao, Yaying
author_sort Shen, Guoqiang
collection PubMed
description Toxoplasmosis, a neglected tropical disease caused by the protozoan parasite Toxoplasma gondii, occurs throughout the world. Human T. gondii infection is asymptomatic in 80% of the population; however, the infection is life-threatening and causes substantial neurologic damage in immunocompromised patients such as HIV-infected persons. The major purpose of this study was to investigate the seroprevalence of T. gondii infection in subjects infected with HIV/AIDS in eastern China. Our findings showed 9.7% prevalence of anti-T. gondii IgG antibody in HIV/AIDS patients, which was higher than in intravenous drug users (2.2%) and healthy controls (4.7%), while no significant difference was observed in the seroprevalence of anti-Toxoplasma IgM antibody among all participants (P>0.05). Among all HIV/AIDS patients, 15 men (7.7%) and 10 women (15.9%) were positive for anti-T. gondii IgG antibody; however, no significant difference was detected in the seroprevalence of anti-Toxoplasma IgG antibody between males and females. The frequency of anti-Toxoplasma IgG antibody was 8.0%, 13.2%, 5.5%, and 0% in patients with normal immune function (CD4(+) T-lymphocyte count ≥500 cells/ml), immunocompromised patients (cell count ≥200 and <500 cells/ml), severely immunocompromised patients (cell count ≥50 and <200 cells/ml), and advanced AIDS patients, respectively (cell count <50 cells/ml), while only 3 immunocompromised patients were positive for anti-T. gondii IgM antibody. The results indicate a high seroprevalence of T. gondii infection in HIV/AIDS patients in eastern China, and a preventive therapy for toxoplasmosis may be given to HIV/AIDS patients based on CD4(+) T lymphocyte count.
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spelling pubmed-47923202016-03-17 Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China Shen, Guoqiang Wang, Xiaoming Sun, Hui Gao, Yaying Korean J Parasitol Brief Communication Toxoplasmosis, a neglected tropical disease caused by the protozoan parasite Toxoplasma gondii, occurs throughout the world. Human T. gondii infection is asymptomatic in 80% of the population; however, the infection is life-threatening and causes substantial neurologic damage in immunocompromised patients such as HIV-infected persons. The major purpose of this study was to investigate the seroprevalence of T. gondii infection in subjects infected with HIV/AIDS in eastern China. Our findings showed 9.7% prevalence of anti-T. gondii IgG antibody in HIV/AIDS patients, which was higher than in intravenous drug users (2.2%) and healthy controls (4.7%), while no significant difference was observed in the seroprevalence of anti-Toxoplasma IgM antibody among all participants (P>0.05). Among all HIV/AIDS patients, 15 men (7.7%) and 10 women (15.9%) were positive for anti-T. gondii IgG antibody; however, no significant difference was detected in the seroprevalence of anti-Toxoplasma IgG antibody between males and females. The frequency of anti-Toxoplasma IgG antibody was 8.0%, 13.2%, 5.5%, and 0% in patients with normal immune function (CD4(+) T-lymphocyte count ≥500 cells/ml), immunocompromised patients (cell count ≥200 and <500 cells/ml), severely immunocompromised patients (cell count ≥50 and <200 cells/ml), and advanced AIDS patients, respectively (cell count <50 cells/ml), while only 3 immunocompromised patients were positive for anti-T. gondii IgM antibody. The results indicate a high seroprevalence of T. gondii infection in HIV/AIDS patients in eastern China, and a preventive therapy for toxoplasmosis may be given to HIV/AIDS patients based on CD4(+) T lymphocyte count. The Korean Society for Parasitology and Tropical Medicine 2016-02 2016-02-26 /pmc/articles/PMC4792320/ /pubmed/26951986 http://dx.doi.org/10.3347/kjp.2016.54.1.93 Text en © 2016, Korean Society for Parasitology and Tropical Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Shen, Guoqiang
Wang, Xiaoming
Sun, Hui
Gao, Yaying
Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title_full Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title_fullStr Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title_full_unstemmed Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title_short Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China
title_sort seroprevalence of toxoplasma gondii infection among hiv/aids patients in eastern china
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792320/
https://www.ncbi.nlm.nih.gov/pubmed/26951986
http://dx.doi.org/10.3347/kjp.2016.54.1.93
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