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Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices
Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous models did not consider the diversity of obstructive sleep apnea (OSA) patients’ characteristics and phenotypes. The object...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792477/ https://www.ncbi.nlm.nih.gov/pubmed/26978077 http://dx.doi.org/10.1371/journal.pone.0151530 |
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author | Isetta, Valentina Montserrat, Josep M. Santano, Raquel Wimms, Alison J. Ramanan, Dinesh Woehrle, Holger Navajas, Daniel Farré, Ramon |
author_facet | Isetta, Valentina Montserrat, Josep M. Santano, Raquel Wimms, Alison J. Ramanan, Dinesh Woehrle, Holger Navajas, Daniel Farré, Ramon |
author_sort | Isetta, Valentina |
collection | PubMed |
description | Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous models did not consider the diversity of obstructive sleep apnea (OSA) patients’ characteristics and phenotypes. The objective of this proof-of-concept study was to design a new bench test for realistically simulating an OSA patient’s night, and to implement a one-night example of a typical female phenotype for comparing responses to several currently-available APAP devices. We developed a novel approach aimed at replicating a typical night of sleep which includes different disturbed breathing events, disease severities, sleep/wake phases, body postures and respiratory artefacts. The simulated female OSA patient example that we implemented included periods of wake, light sleep and deep sleep with positional changes and was connected to ten different APAP devices. Flow and pressure readings were recorded; each device was tested twice. The new approach for simulating female OSA patients effectively combined a wide variety of disturbed breathing patterns to mimic the response of a predefined patient type. There were marked differences in response between devices; only three were able to overcome flow limitation to normalize breathing, and only five devices were associated with a residual apnea-hypopnea index of <5/h. In conclusion, bench tests can be designed to simulate specific patient characteristics, and typical stages of sleep, body position, and wake. Each APAP device behaved differently when exposed to this controlled model of a female OSA patient, and should lead to further understanding of OSA treatment. |
format | Online Article Text |
id | pubmed-4792477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47924772016-03-23 Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices Isetta, Valentina Montserrat, Josep M. Santano, Raquel Wimms, Alison J. Ramanan, Dinesh Woehrle, Holger Navajas, Daniel Farré, Ramon PLoS One Research Article Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous models did not consider the diversity of obstructive sleep apnea (OSA) patients’ characteristics and phenotypes. The objective of this proof-of-concept study was to design a new bench test for realistically simulating an OSA patient’s night, and to implement a one-night example of a typical female phenotype for comparing responses to several currently-available APAP devices. We developed a novel approach aimed at replicating a typical night of sleep which includes different disturbed breathing events, disease severities, sleep/wake phases, body postures and respiratory artefacts. The simulated female OSA patient example that we implemented included periods of wake, light sleep and deep sleep with positional changes and was connected to ten different APAP devices. Flow and pressure readings were recorded; each device was tested twice. The new approach for simulating female OSA patients effectively combined a wide variety of disturbed breathing patterns to mimic the response of a predefined patient type. There were marked differences in response between devices; only three were able to overcome flow limitation to normalize breathing, and only five devices were associated with a residual apnea-hypopnea index of <5/h. In conclusion, bench tests can be designed to simulate specific patient characteristics, and typical stages of sleep, body position, and wake. Each APAP device behaved differently when exposed to this controlled model of a female OSA patient, and should lead to further understanding of OSA treatment. Public Library of Science 2016-03-15 /pmc/articles/PMC4792477/ /pubmed/26978077 http://dx.doi.org/10.1371/journal.pone.0151530 Text en © 2016 Isetta et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Isetta, Valentina Montserrat, Josep M. Santano, Raquel Wimms, Alison J. Ramanan, Dinesh Woehrle, Holger Navajas, Daniel Farré, Ramon Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title | Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title_full | Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title_fullStr | Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title_full_unstemmed | Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title_short | Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices |
title_sort | novel approach to simulate sleep apnea patients for evaluating positive pressure therapy devices |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792477/ https://www.ncbi.nlm.nih.gov/pubmed/26978077 http://dx.doi.org/10.1371/journal.pone.0151530 |
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