PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins

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Proteins with expanded polyglutamine (polyQ) repeats are involved in human neurodegenerative diseases, via a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of β-sheet-rich aggregates. Aggregation is dependent on th...

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Detalles Bibliográficos
Autores principales: Li, Chen, Nagel, Jeremy, Androulakis, Steve, Song, Jiangning, Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Database Update
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792530/
https://www.ncbi.nlm.nih.gov/pubmed/26980520
http://dx.doi.org/10.1093/database/baw021

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