Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

Multidrug resistance (MDR) is the leading cause of treatment failure in cancer chemotherapy. The overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2, play a key role in mediating MDR by pumping anticancer drugs out from cancer cells. Ceritinib (LDK378) is a...

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Detalles Bibliográficos
Autores principales: Hu, Jing, Zhang, Xu, Wang, Fang, Wang, Xiaokun, Yang, Ke, Xu, Meng, To, Kenneth K.W., Li, Qingshan, Fu, Liwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792582/
https://www.ncbi.nlm.nih.gov/pubmed/26556876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792582/
https://www.ncbi.nlm.nih.gov/pubmed/26556876

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