Mutant p53 induces EZH2 expression and promotes epithelial–mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing

The tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression. Here, we report that mutant p53 (mutp53) promotes EMT in...

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Detalles Bibliográficos
Autores principales: Jiang, Fei-Zhou, He, Yin-Yan, Wang, Hui-Hui, Zhang, Hui-Lin, Zhang, Jian, Yan, Xiao-Fang, Wang, Xiao-Jun, Che, Qi, Ke, Jie-Qi, Chen, Zheng, Tong, Huan, Zhang, Yong-Li, Wang, Fang-Yuan, Li, Yi-Ran, Wan, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792583/
https://www.ncbi.nlm.nih.gov/pubmed/26587974

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