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Harnessing the integrated stress response for the treatment of multiple sclerosis
Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system (CNS) with no known cure. Though a dozen immunomodulatory therapies exist, their impact on progression of disease appears limited. The field has hence focused on alternate strategies for treatment suc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792730/ https://www.ncbi.nlm.nih.gov/pubmed/26873788 http://dx.doi.org/10.1016/S1474-4422(15)00381-6 |
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author | Way, Sharon W. Popko, Brian |
author_facet | Way, Sharon W. Popko, Brian |
author_sort | Way, Sharon W. |
collection | PubMed |
description | Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system (CNS) with no known cure. Though a dozen immunomodulatory therapies exist, their impact on progression of disease appears limited. The field has hence focused on alternate strategies for treatment such as enhancing remyelination and CNS repair. Recent progress has been made on a third complimentary treatment approach that involves protecting oligodendrocytes, and the myelin they generate and maintain, from inflammatory-mediated death via enhancement of the integrated stress response (ISR). Studies in cells and mouse models of MS have demonstrated that the ISR, an innate protective pathway that maintains proteostasis, may be effectively harnessed to aid in the protection of oligodendrocytes and myelin during inflammation. With one ISR-modifying drug already in clinical trial and a number of potential future therapies under investigation, this approach may offer an important component in halting the progression of multiple sclerosis. |
format | Online Article Text |
id | pubmed-4792730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-47927302017-04-01 Harnessing the integrated stress response for the treatment of multiple sclerosis Way, Sharon W. Popko, Brian Lancet Neurol Article Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system (CNS) with no known cure. Though a dozen immunomodulatory therapies exist, their impact on progression of disease appears limited. The field has hence focused on alternate strategies for treatment such as enhancing remyelination and CNS repair. Recent progress has been made on a third complimentary treatment approach that involves protecting oligodendrocytes, and the myelin they generate and maintain, from inflammatory-mediated death via enhancement of the integrated stress response (ISR). Studies in cells and mouse models of MS have demonstrated that the ISR, an innate protective pathway that maintains proteostasis, may be effectively harnessed to aid in the protection of oligodendrocytes and myelin during inflammation. With one ISR-modifying drug already in clinical trial and a number of potential future therapies under investigation, this approach may offer an important component in halting the progression of multiple sclerosis. 2016-02-10 2016-04 /pmc/articles/PMC4792730/ /pubmed/26873788 http://dx.doi.org/10.1016/S1474-4422(15)00381-6 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This manuscript version is made available under the CC BY-NC-ND 4.0 license. |
spellingShingle | Article Way, Sharon W. Popko, Brian Harnessing the integrated stress response for the treatment of multiple sclerosis |
title | Harnessing the integrated stress response for the treatment of multiple sclerosis |
title_full | Harnessing the integrated stress response for the treatment of multiple sclerosis |
title_fullStr | Harnessing the integrated stress response for the treatment of multiple sclerosis |
title_full_unstemmed | Harnessing the integrated stress response for the treatment of multiple sclerosis |
title_short | Harnessing the integrated stress response for the treatment of multiple sclerosis |
title_sort | harnessing the integrated stress response for the treatment of multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792730/ https://www.ncbi.nlm.nih.gov/pubmed/26873788 http://dx.doi.org/10.1016/S1474-4422(15)00381-6 |
work_keys_str_mv | AT waysharonw harnessingtheintegratedstressresponseforthetreatmentofmultiplesclerosis AT popkobrian harnessingtheintegratedstressresponseforthetreatmentofmultiplesclerosis |