Ascorbic acid serum levels are reduced in patients with hematological malignancies

In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells fro...

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Detalles Bibliográficos
Autores principales: Huijskens, Mirelle J.A.J., Wodzig, Will K.W.H., Walczak, Mateusz, Germeraad, Wilfred T.V., Bos, Gerard M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792862/
https://www.ncbi.nlm.nih.gov/pubmed/27014565
http://dx.doi.org/10.1016/j.rinim.2016.01.001
Descripción
Sumario:In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

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