Ascorbic acid serum levels are reduced in patients with hematological malignancies

In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells fro...

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Autores principales: Huijskens, Mirelle J.A.J., Wodzig, Will K.W.H., Walczak, Mateusz, Germeraad, Wilfred T.V., Bos, Gerard M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792862/
https://www.ncbi.nlm.nih.gov/pubmed/27014565
http://dx.doi.org/10.1016/j.rinim.2016.01.001
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author Huijskens, Mirelle J.A.J.
Wodzig, Will K.W.H.
Walczak, Mateusz
Germeraad, Wilfred T.V.
Bos, Gerard M.J.
author_facet Huijskens, Mirelle J.A.J.
Wodzig, Will K.W.H.
Walczak, Mateusz
Germeraad, Wilfred T.V.
Bos, Gerard M.J.
author_sort Huijskens, Mirelle J.A.J.
collection PubMed
description In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.
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spelling pubmed-47928622016-03-24 Ascorbic acid serum levels are reduced in patients with hematological malignancies Huijskens, Mirelle J.A.J. Wodzig, Will K.W.H. Walczak, Mateusz Germeraad, Wilfred T.V. Bos, Gerard M.J. Results Immunol Short Communication In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation. Elsevier 2016-01-12 /pmc/articles/PMC4792862/ /pubmed/27014565 http://dx.doi.org/10.1016/j.rinim.2016.01.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Huijskens, Mirelle J.A.J.
Wodzig, Will K.W.H.
Walczak, Mateusz
Germeraad, Wilfred T.V.
Bos, Gerard M.J.
Ascorbic acid serum levels are reduced in patients with hematological malignancies
title Ascorbic acid serum levels are reduced in patients with hematological malignancies
title_full Ascorbic acid serum levels are reduced in patients with hematological malignancies
title_fullStr Ascorbic acid serum levels are reduced in patients with hematological malignancies
title_full_unstemmed Ascorbic acid serum levels are reduced in patients with hematological malignancies
title_short Ascorbic acid serum levels are reduced in patients with hematological malignancies
title_sort ascorbic acid serum levels are reduced in patients with hematological malignancies
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792862/
https://www.ncbi.nlm.nih.gov/pubmed/27014565
http://dx.doi.org/10.1016/j.rinim.2016.01.001
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