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Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films

Carbon plasma nanocoatings with controlled fraction of sp(3)-C bonding were deposited on TiO(2) nanorod arrays (TNAs) by DC magnetic-filtered cathodic vacuum arc deposition (FCVAD). The cytocompatibility of TNA/carbon nanocomposites was systematically investigated. Human umbilical vein endothelial c...

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Detalles Bibliográficos
Autores principales: Chen, Hongpeng, Tang, Nan, Chen, Min, Chen, Dihu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792867/
https://www.ncbi.nlm.nih.gov/pubmed/26979723
http://dx.doi.org/10.1186/s11671-016-1358-0
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author Chen, Hongpeng
Tang, Nan
Chen, Min
Chen, Dihu
author_facet Chen, Hongpeng
Tang, Nan
Chen, Min
Chen, Dihu
author_sort Chen, Hongpeng
collection PubMed
description Carbon plasma nanocoatings with controlled fraction of sp(3)-C bonding were deposited on TiO(2) nanorod arrays (TNAs) by DC magnetic-filtered cathodic vacuum arc deposition (FCVAD). The cytocompatibility of TNA/carbon nanocomposites was systematically investigated. Human umbilical vein endothelial cells (HUVECs) were cultured on the nanocomposites for 4, 24, and 72 h in vitro. It was found that plasma-treated TNAs exhibited excellent cell viability as compared to the untreated. Importantly, our results show that cellular responses positively correlate with the sp(3)-C content. The cells cultured on high sp(3)-C-contented substrates exhibit better attachment, shape configuration, and proliferation. These findings indicate that the nanocomposites with high sp(3)-C content possessed superior cytocompatibility. Notably, the nanocomposites drastically reduced platelet adhesion and activation in our previous studies. Taken together, these findings suggest the TNA/carbon scaffold may serve as a guide for the design of multi-functionality devices that promotes endothelialization and improves hemocompatibility.
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spelling pubmed-47928672016-04-09 Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films Chen, Hongpeng Tang, Nan Chen, Min Chen, Dihu Nanoscale Res Lett Nano Express Carbon plasma nanocoatings with controlled fraction of sp(3)-C bonding were deposited on TiO(2) nanorod arrays (TNAs) by DC magnetic-filtered cathodic vacuum arc deposition (FCVAD). The cytocompatibility of TNA/carbon nanocomposites was systematically investigated. Human umbilical vein endothelial cells (HUVECs) were cultured on the nanocomposites for 4, 24, and 72 h in vitro. It was found that plasma-treated TNAs exhibited excellent cell viability as compared to the untreated. Importantly, our results show that cellular responses positively correlate with the sp(3)-C content. The cells cultured on high sp(3)-C-contented substrates exhibit better attachment, shape configuration, and proliferation. These findings indicate that the nanocomposites with high sp(3)-C content possessed superior cytocompatibility. Notably, the nanocomposites drastically reduced platelet adhesion and activation in our previous studies. Taken together, these findings suggest the TNA/carbon scaffold may serve as a guide for the design of multi-functionality devices that promotes endothelialization and improves hemocompatibility. Springer US 2016-03-15 /pmc/articles/PMC4792867/ /pubmed/26979723 http://dx.doi.org/10.1186/s11671-016-1358-0 Text en © Chen et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Chen, Hongpeng
Tang, Nan
Chen, Min
Chen, Dihu
Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title_full Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title_fullStr Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title_full_unstemmed Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title_short Endothelialization of TiO(2) Nanorods Coated with Ultrathin Amorphous Carbon Films
title_sort endothelialization of tio(2) nanorods coated with ultrathin amorphous carbon films
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792867/
https://www.ncbi.nlm.nih.gov/pubmed/26979723
http://dx.doi.org/10.1186/s11671-016-1358-0
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