Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemica...

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Detalles Bibliográficos
Autores principales: Aina, Adeyinka, Gupta, Manish, Boukari, Yamina, Morris, Andrew, Billa, Nashiru, Doughty, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792904/
https://www.ncbi.nlm.nih.gov/pubmed/27013917
http://dx.doi.org/10.1016/j.jsps.2015.03.015
Descripción
Sumario:The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

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