Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemica...

Descripción completa

Detalles Bibliográficos
Autores principales: Aina, Adeyinka, Gupta, Manish, Boukari, Yamina, Morris, Andrew, Billa, Nashiru, Doughty, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792904/
https://www.ncbi.nlm.nih.gov/pubmed/27013917
http://dx.doi.org/10.1016/j.jsps.2015.03.015
_version_ 1782421303967350784
author Aina, Adeyinka
Gupta, Manish
Boukari, Yamina
Morris, Andrew
Billa, Nashiru
Doughty, Stephen
author_facet Aina, Adeyinka
Gupta, Manish
Boukari, Yamina
Morris, Andrew
Billa, Nashiru
Doughty, Stephen
author_sort Aina, Adeyinka
collection PubMed
description The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.
format Online
Article
Text
id pubmed-4792904
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47929042016-03-24 Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction Aina, Adeyinka Gupta, Manish Boukari, Yamina Morris, Andrew Billa, Nashiru Doughty, Stephen Saudi Pharm J Short Communication The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture. Elsevier 2016-03 2015-03-21 /pmc/articles/PMC4792904/ /pubmed/27013917 http://dx.doi.org/10.1016/j.jsps.2015.03.015 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Aina, Adeyinka
Gupta, Manish
Boukari, Yamina
Morris, Andrew
Billa, Nashiru
Doughty, Stephen
Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title_full Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title_fullStr Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title_full_unstemmed Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title_short Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction
title_sort monitoring model drug microencapsulation in plga scaffolds using x-ray powder diffraction
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792904/
https://www.ncbi.nlm.nih.gov/pubmed/27013917
http://dx.doi.org/10.1016/j.jsps.2015.03.015
work_keys_str_mv AT ainaadeyinka monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction
AT guptamanish monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction
AT boukariyamina monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction
AT morrisandrew monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction
AT billanashiru monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction
AT doughtystephen monitoringmodeldrugmicroencapsulationinplgascaffoldsusingxraypowderdiffraction

Ejemplares similares