IL-17-producing γδ T cells enhance bone regeneration

Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of...

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Autores principales: Ono, Takehito, Okamoto, Kazuo, Nakashima, Tomoki, Nitta, Takeshi, Hori, Shohei, Iwakura, Yoichiro, Takayanagi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792964/
https://www.ncbi.nlm.nih.gov/pubmed/26965320
http://dx.doi.org/10.1038/ncomms10928
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author Ono, Takehito
Okamoto, Kazuo
Nakashima, Tomoki
Nitta, Takeshi
Hori, Shohei
Iwakura, Yoichiro
Takayanagi, Hiroshi
author_facet Ono, Takehito
Okamoto, Kazuo
Nakashima, Tomoki
Nitta, Takeshi
Hori, Shohei
Iwakura, Yoichiro
Takayanagi, Hiroshi
author_sort Ono, Takehito
collection PubMed
description Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.
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spelling pubmed-47929642016-03-21 IL-17-producing γδ T cells enhance bone regeneration Ono, Takehito Okamoto, Kazuo Nakashima, Tomoki Nitta, Takeshi Hori, Shohei Iwakura, Yoichiro Takayanagi, Hiroshi Nat Commun Article Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration. Nature Publishing Group 2016-03-11 /pmc/articles/PMC4792964/ /pubmed/26965320 http://dx.doi.org/10.1038/ncomms10928 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ono, Takehito
Okamoto, Kazuo
Nakashima, Tomoki
Nitta, Takeshi
Hori, Shohei
Iwakura, Yoichiro
Takayanagi, Hiroshi
IL-17-producing γδ T cells enhance bone regeneration
title IL-17-producing γδ T cells enhance bone regeneration
title_full IL-17-producing γδ T cells enhance bone regeneration
title_fullStr IL-17-producing γδ T cells enhance bone regeneration
title_full_unstemmed IL-17-producing γδ T cells enhance bone regeneration
title_short IL-17-producing γδ T cells enhance bone regeneration
title_sort il-17-producing γδ t cells enhance bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792964/
https://www.ncbi.nlm.nih.gov/pubmed/26965320
http://dx.doi.org/10.1038/ncomms10928
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