The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essent...

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Detalles Bibliográficos
Autores principales: Murai, Kiyohito, Sun, Guoqiang, Ye, Peng, Tian, E., Yang, Su, Cui, Qi, Sun, Guihua, Trinh, Daniel, Sun, Olivia, Hong, Teresa, Wen, Zhexing, Kalkum, Markus, Riggs, Arthur D., Song, Hongjun, Ming, Guo-li, Shi, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793043/
https://www.ncbi.nlm.nih.gov/pubmed/26965827
http://dx.doi.org/10.1038/ncomms10965

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