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Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells

The interaction of tumor cells with the microenvironment is like a relationship between the “seeds” and “soil,” which is a hotspot in recent cancer research. Targeting at tumor microenvironment as well as tumor cells has become a new strategy for cancer treatment. Conventional cancer treatments most...

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Detalles Bibliográficos
Autores principales: Xu, Jingnan, Song, Zhuo, Guo, Qiujun, Li, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793102/
https://www.ncbi.nlm.nih.gov/pubmed/27042656
http://dx.doi.org/10.1155/2016/1490738
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author Xu, Jingnan
Song, Zhuo
Guo, Qiujun
Li, Jie
author_facet Xu, Jingnan
Song, Zhuo
Guo, Qiujun
Li, Jie
author_sort Xu, Jingnan
collection PubMed
description The interaction of tumor cells with the microenvironment is like a relationship between the “seeds” and “soil,” which is a hotspot in recent cancer research. Targeting at tumor microenvironment as well as tumor cells has become a new strategy for cancer treatment. Conventional cancer treatments mostly focused on single targets or single mechanism (the seeds or part of the soil); few researches intervened in the whole tumor microenvironment and achieved ideal therapeutic effect as expected. Traditional Chinese medicine displays a broad range of biological effects, and increasing evidence has shown that it may relate with synergistic effect on regulating tumor microenvironment and cancer cells. Based on literature review and our previous studies, we summarize the synergistic effect and the molecular mechanisms of traditional Chinese medicine on regulating tumor microenvironment and cancer cells.
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spelling pubmed-47931022016-04-03 Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells Xu, Jingnan Song, Zhuo Guo, Qiujun Li, Jie Biomed Res Int Review Article The interaction of tumor cells with the microenvironment is like a relationship between the “seeds” and “soil,” which is a hotspot in recent cancer research. Targeting at tumor microenvironment as well as tumor cells has become a new strategy for cancer treatment. Conventional cancer treatments mostly focused on single targets or single mechanism (the seeds or part of the soil); few researches intervened in the whole tumor microenvironment and achieved ideal therapeutic effect as expected. Traditional Chinese medicine displays a broad range of biological effects, and increasing evidence has shown that it may relate with synergistic effect on regulating tumor microenvironment and cancer cells. Based on literature review and our previous studies, we summarize the synergistic effect and the molecular mechanisms of traditional Chinese medicine on regulating tumor microenvironment and cancer cells. Hindawi Publishing Corporation 2016 2016-03-02 /pmc/articles/PMC4793102/ /pubmed/27042656 http://dx.doi.org/10.1155/2016/1490738 Text en Copyright © 2016 Jingnan Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Jingnan
Song, Zhuo
Guo, Qiujun
Li, Jie
Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title_full Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title_fullStr Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title_full_unstemmed Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title_short Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
title_sort synergistic effect and molecular mechanisms of traditional chinese medicine on regulating tumor microenvironment and cancer cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793102/
https://www.ncbi.nlm.nih.gov/pubmed/27042656
http://dx.doi.org/10.1155/2016/1490738
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