Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains

TDP-43 is the major disease-associated protein involved in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions linked to TDP-43 pathology (FTLD-TDP). Abnormal phosphorylation, truncation and cytoplasmic mis-...

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Detalles Bibliográficos
Autores principales: Kametani, Fuyuki, Obi, Tomokazu, Shishido, Takeo, Akatsu, Hiroyasu, Murayama, Shigeo, Saito, Yuko, Yoshida, Mari, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793195/
https://www.ncbi.nlm.nih.gov/pubmed/26980269
http://dx.doi.org/10.1038/srep23281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793195/
https://www.ncbi.nlm.nih.gov/pubmed/26980269
http://dx.doi.org/10.1038/srep23281

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