Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance

Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increa...

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Detalles Bibliográficos
Autores principales: Dulka, Brooke N., Ford, Ellen C., Lee, Melissa A., Donnell, Nathaniel J., Goode, Travis D., Prosser, Rebecca, Cooper, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793198/
https://www.ncbi.nlm.nih.gov/pubmed/26980783
http://dx.doi.org/10.1101/lm.040253.115
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author Dulka, Brooke N.
Ford, Ellen C.
Lee, Melissa A.
Donnell, Nathaniel J.
Goode, Travis D.
Prosser, Rebecca
Cooper, Matthew A.
author_facet Dulka, Brooke N.
Ford, Ellen C.
Lee, Melissa A.
Donnell, Nathaniel J.
Goode, Travis D.
Prosser, Rebecca
Cooper, Matthew A.
author_sort Dulka, Brooke N.
collection PubMed
description Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increases the expression of mBDNF, but not proBDNF, in the BLA/central amygdala. We also showed that blocking plasmin in the BLA with microinjection of α(2)-antiplasmin immediately following social defeat decreases social avoidance 24 h later. These data suggest the proteolytic cleavage of BDNF in the BLA is necessary for defeat-induced social avoidance.
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spelling pubmed-47931982017-04-01 Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance Dulka, Brooke N. Ford, Ellen C. Lee, Melissa A. Donnell, Nathaniel J. Goode, Travis D. Prosser, Rebecca Cooper, Matthew A. Learn Mem Brief Communication Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increases the expression of mBDNF, but not proBDNF, in the BLA/central amygdala. We also showed that blocking plasmin in the BLA with microinjection of α(2)-antiplasmin immediately following social defeat decreases social avoidance 24 h later. These data suggest the proteolytic cleavage of BDNF in the BLA is necessary for defeat-induced social avoidance. Cold Spring Harbor Laboratory Press 2016-04 /pmc/articles/PMC4793198/ /pubmed/26980783 http://dx.doi.org/10.1101/lm.040253.115 Text en © 2016 Dulka et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Dulka, Brooke N.
Ford, Ellen C.
Lee, Melissa A.
Donnell, Nathaniel J.
Goode, Travis D.
Prosser, Rebecca
Cooper, Matthew A.
Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title_full Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title_fullStr Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title_full_unstemmed Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title_short Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance
title_sort proteolytic cleavage of probdnf into mature bdnf in the basolateral amygdala is necessary for defeat-induced social avoidance
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793198/
https://www.ncbi.nlm.nih.gov/pubmed/26980783
http://dx.doi.org/10.1101/lm.040253.115
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