The Hippo pathway member YAP enhances human neural crest cell fate and migration

The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and regulates key processes during development and tumorigenesis. The neural crest is an embryonic tissue known to respond to multiple environmental cues in order to acquire appropriate cell fate and migration proper...

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Autores principales: Hindley, Christopher J., Condurat, Alexandra Larisa, Menon, Vishal, Thomas, Ria, Azmitia, Luis M., Davis, Jason A., Pruszak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793290/
https://www.ncbi.nlm.nih.gov/pubmed/26980066
http://dx.doi.org/10.1038/srep23208
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author Hindley, Christopher J.
Condurat, Alexandra Larisa
Menon, Vishal
Thomas, Ria
Azmitia, Luis M.
Davis, Jason A.
Pruszak, Jan
author_facet Hindley, Christopher J.
Condurat, Alexandra Larisa
Menon, Vishal
Thomas, Ria
Azmitia, Luis M.
Davis, Jason A.
Pruszak, Jan
author_sort Hindley, Christopher J.
collection PubMed
description The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and regulates key processes during development and tumorigenesis. The neural crest is an embryonic tissue known to respond to multiple environmental cues in order to acquire appropriate cell fate and migration properties. Using multiple in vitro models of human neural development (pluripotent stem cell-derived neural stem cells; LUHMES, NTERA2 and SH-SY5Y cell lines), we investigated the role of Hippo/YAP signaling in neural differentiation and neural crest development. We report that the activity of YAP promotes an early neural crest phenotype and migration, and provide the first evidence for an interaction between Hippo/YAP and retinoic acid signaling in this system.
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spelling pubmed-47932902016-03-17 The Hippo pathway member YAP enhances human neural crest cell fate and migration Hindley, Christopher J. Condurat, Alexandra Larisa Menon, Vishal Thomas, Ria Azmitia, Luis M. Davis, Jason A. Pruszak, Jan Sci Rep Article The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and regulates key processes during development and tumorigenesis. The neural crest is an embryonic tissue known to respond to multiple environmental cues in order to acquire appropriate cell fate and migration properties. Using multiple in vitro models of human neural development (pluripotent stem cell-derived neural stem cells; LUHMES, NTERA2 and SH-SY5Y cell lines), we investigated the role of Hippo/YAP signaling in neural differentiation and neural crest development. We report that the activity of YAP promotes an early neural crest phenotype and migration, and provide the first evidence for an interaction between Hippo/YAP and retinoic acid signaling in this system. Nature Publishing Group 2016-03-16 /pmc/articles/PMC4793290/ /pubmed/26980066 http://dx.doi.org/10.1038/srep23208 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hindley, Christopher J.
Condurat, Alexandra Larisa
Menon, Vishal
Thomas, Ria
Azmitia, Luis M.
Davis, Jason A.
Pruszak, Jan
The Hippo pathway member YAP enhances human neural crest cell fate and migration
title The Hippo pathway member YAP enhances human neural crest cell fate and migration
title_full The Hippo pathway member YAP enhances human neural crest cell fate and migration
title_fullStr The Hippo pathway member YAP enhances human neural crest cell fate and migration
title_full_unstemmed The Hippo pathway member YAP enhances human neural crest cell fate and migration
title_short The Hippo pathway member YAP enhances human neural crest cell fate and migration
title_sort hippo pathway member yap enhances human neural crest cell fate and migration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793290/
https://www.ncbi.nlm.nih.gov/pubmed/26980066
http://dx.doi.org/10.1038/srep23208
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