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Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia

BACKGROUND: Juvenile myelomonocytic leukemia (JMML) is a fatal, myelodysplastic/myeloproliferative neoplasm of early childhood. Patients with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR, CD116) signaling pathway. Allog...

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Detalles Bibliográficos
Autores principales:	Nakazawa, Yozo, Matsuda, Kazuyuki, Kurata, Takashi, Sueki, Akane, Tanaka, Miyuki, Sakashita, Kazuo, Imai, Chihaya, Wilson, Matthew H., Koike, Kenichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793548/ https://www.ncbi.nlm.nih.gov/pubmed/26983639 http://dx.doi.org/10.1186/s13045-016-0256-3

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