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Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure

Although the incidence and mortality for most cancers such as lung and colon are decreasing in several countries, they are increasing in several developed countries because of an unhealthy western lifestyles including smoking, physical inactivity and consumption of calorie-dense food. The incidences...

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Autores principales: Choi, Jung Ran, Park, Seong Yong, Noh, O Kyu, Koh, Young Wha, Kang, Dae Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793700/
https://www.ncbi.nlm.nih.gov/pubmed/26985396
http://dx.doi.org/10.1186/s40557-016-0095-2
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author Choi, Jung Ran
Park, Seong Yong
Noh, O Kyu
Koh, Young Wha
Kang, Dae Ryong
author_facet Choi, Jung Ran
Park, Seong Yong
Noh, O Kyu
Koh, Young Wha
Kang, Dae Ryong
author_sort Choi, Jung Ran
collection PubMed
description Although the incidence and mortality for most cancers such as lung and colon are decreasing in several countries, they are increasing in several developed countries because of an unhealthy western lifestyles including smoking, physical inactivity and consumption of calorie-dense food. The incidences for lung and colon cancers in a few of these countries have already exceeded those in the United States and other western countries. Among them, lung cancer is the main cause of cancer death in worldwide. The cumulative survival rate at five years differs between 13 and 21 % in several countries. Although the most important risk factors are smoking for lung cancer, however, the increased incidence of lung cancer in never smokers(LCINS) is necessary to improve knowledge concerning other risk factors. Environmental factors and genetic susceptibility are also thought to contribute to lung cancer risk. Patients with lung adenocarcinoma who have never smoking frequently contain mutation within tyrosine kinase domain of the epidermal growth factor receptor(EGFR) gene. Also, K-ras mutations are more common in individuals with a history of smoking use and are related with resistance to EFGR-tyrosine kinase inhibitors. Recently, radon(Rn), natural and noble gas, has been recognized as second common reason of lung cancer. In this review, we aim to know whether residential radon is associated with an increased risk for developing lung cancer and regulated by several genetic polymorphisms.
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spelling pubmed-47937002016-03-17 Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure Choi, Jung Ran Park, Seong Yong Noh, O Kyu Koh, Young Wha Kang, Dae Ryong Ann Occup Environ Med Review Although the incidence and mortality for most cancers such as lung and colon are decreasing in several countries, they are increasing in several developed countries because of an unhealthy western lifestyles including smoking, physical inactivity and consumption of calorie-dense food. The incidences for lung and colon cancers in a few of these countries have already exceeded those in the United States and other western countries. Among them, lung cancer is the main cause of cancer death in worldwide. The cumulative survival rate at five years differs between 13 and 21 % in several countries. Although the most important risk factors are smoking for lung cancer, however, the increased incidence of lung cancer in never smokers(LCINS) is necessary to improve knowledge concerning other risk factors. Environmental factors and genetic susceptibility are also thought to contribute to lung cancer risk. Patients with lung adenocarcinoma who have never smoking frequently contain mutation within tyrosine kinase domain of the epidermal growth factor receptor(EGFR) gene. Also, K-ras mutations are more common in individuals with a history of smoking use and are related with resistance to EFGR-tyrosine kinase inhibitors. Recently, radon(Rn), natural and noble gas, has been recognized as second common reason of lung cancer. In this review, we aim to know whether residential radon is associated with an increased risk for developing lung cancer and regulated by several genetic polymorphisms. BioMed Central 2016-03-16 /pmc/articles/PMC4793700/ /pubmed/26985396 http://dx.doi.org/10.1186/s40557-016-0095-2 Text en © Choi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Choi, Jung Ran
Park, Seong Yong
Noh, O Kyu
Koh, Young Wha
Kang, Dae Ryong
Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title_full Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title_fullStr Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title_full_unstemmed Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title_short Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
title_sort gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793700/
https://www.ncbi.nlm.nih.gov/pubmed/26985396
http://dx.doi.org/10.1186/s40557-016-0095-2
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