Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis

BACKGROUND: The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T–B interactions and production of pro-inflammatory cytokines. Receptor activator of nuclear factor κB ligand (RANKL) is a key cytokine invol...

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Detalles Bibliográficos
Autores principales: Ota, Yuri, Niiro, Hiroaki, Ota, Shun-ichiro, Ueki, Naoko, Tsuzuki, Hirofumi, Nakayama, Tsuyoshi, Mishima, Koji, Higashioka, Kazuhiko, Jabbarzadeh-Tabrizi, Siamak, Mitoma, Hiroki, Akahoshi, Mitsuteru, Arinobu, Yojiro, Kukita, Akiko, Yamada, Hisakata, Tsukamoto, Hiroshi, Akashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793760/
https://www.ncbi.nlm.nih.gov/pubmed/26980135
http://dx.doi.org/10.1186/s13075-016-0957-6

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