Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis

BACKGROUND: Optimum efficiency of the folate pathway is considered essential for adequate ovarian function. 677 C>T substitution in the 5, 10-methylene tertrahydrofolatereductase (MTHFR) gene compromises activity of the MTHFR enzyme by about 50%. The significance of correlation between 677C>T...

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Detalles Bibliográficos
Autores principales: Carlus, S. Justin, Sarkar, Saumya, Bansal, Sandeep Kumar, Singh, Vertika, Singh, Kiran, Jha, Rajesh Kumar, Sadasivam, Nirmala, Sadasivam, Sri Revathy, Gireesha, P. S., Thangaraj, Kumarasamy, Rajender, Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794143/
https://www.ncbi.nlm.nih.gov/pubmed/26983014
http://dx.doi.org/10.1371/journal.pone.0151510

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