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Demonstrating Functional Equivalence of Pilot and Production Scale Freeze-Drying of BCG
Process analytical technology (PAT)-tools were used to monitor freeze-drying of Bacille Calmette-Guérin (BCG) at pilot and production scale. Among the evaluated PAT-tools, there is the novel use of the vacuum valve open/close frequency for determining the endpoint of primary drying at production sca...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794149/ https://www.ncbi.nlm.nih.gov/pubmed/26981867 http://dx.doi.org/10.1371/journal.pone.0151239 |