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Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Alterations in DNA damage response and repair have been observed in Huntington’s disease (HD). We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. A significant fraction of the HD iPSC lines had genomic abnormalities as ass...

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Detalles Bibliográficos
Autores principales:	Tidball, Andrew M., Neely, M. Diana, Chamberlin, Reed, Aboud, Asad A., Kumar, Kevin K., Han, Bingying, Bryan, Miles R., Aschner, Michael, Ess, Kevin C., Bowman, Aaron B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794230/ https://www.ncbi.nlm.nih.gov/pubmed/26982737 http://dx.doi.org/10.1371/journal.pone.0150372

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