Angiotensin II increases gene expression after selective intra-arterial adenovirus delivery in a rabbit model assessed using in vivo SSTR2-based reporter imaging

BACKGROUND: Gene therapy has been hampered by low expression upon in vivo delivery. Using a somatostatin receptor type 2 (SSTR2)-based reporter, we assessed whether angiotensin II (AII) can improve gene expression by adenovirus upon intra-arterial (IA) delivery in a large animal model. METHODS: A SS...

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Detalles Bibliográficos
Autores principales: Singh, Sheela P., Ravoori, Murali K., Dixon, Katherine A., Han, Lin, Gupta, Sanjay, Uthamanthil, Rajesh, Wright, Kenneth C., Kundra, Vikas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794473/
https://www.ncbi.nlm.nih.gov/pubmed/26983635
http://dx.doi.org/10.1186/s13550-016-0183-x

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