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Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery

OBJECTIVE: To observe the influence of psychological intervention on pain, immune system and adrenocortical functions of patients receiving lung cancer surgery. METHODS: We selected 124 patients who received surgery for treating stage I or II lung cancer and divided into experimental group and contr...

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Autores principales: Zhao, Xinying, Cui, Limin, Wang, Wei, Su, Quanzhi, Li, Xiuzhi, Wu, Junben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794516/
https://www.ncbi.nlm.nih.gov/pubmed/27022366
http://dx.doi.org/10.12669/pjms.321.8935
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author Zhao, Xinying
Cui, Limin
Wang, Wei
Su, Quanzhi
Li, Xiuzhi
Wu, Junben
author_facet Zhao, Xinying
Cui, Limin
Wang, Wei
Su, Quanzhi
Li, Xiuzhi
Wu, Junben
author_sort Zhao, Xinying
collection PubMed
description OBJECTIVE: To observe the influence of psychological intervention on pain, immune system and adrenocortical functions of patients receiving lung cancer surgery. METHODS: We selected 124 patients who received surgery for treating stage I or II lung cancer and divided into experimental group and control group. The experimental group received comprehensive psychological intervention while the control group was given conventional nursing intervention. Pain of patients in two groups was evaluated by visual analog scale (VAS). Before and after intervention, CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) and free cortisol level in serum were measured. Moreover, QLQ-C30, a life quality measurement scale developed by European Organization for Research and Treatment of Cancer (EORTC) was used. RESULTS: Compared to control group, VAS of patients in experimental group remarkably decreased before anesthesia, 6 hour, 12 hour 24 hour and 48 hour after surgery (P<0.05), and moreover, OLQ-C30 score and various factor scores (except physical symptoms) in experimental group were much higher (P<0.05). No statistical significant difference was found in immune index between two groups before intervention (P>0.05). Differences of CD3(+) and CD4(+) before and after intervention were both statistically significant (P<0.05), so did free cortisol level (P<0.05). CONCLUSION: Comprehensive psychological intervention can effectively relieve pain, improve immune functions and enhance quality of life for patients suffering from lung cancer surgery.
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spelling pubmed-47945162016-03-28 Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery Zhao, Xinying Cui, Limin Wang, Wei Su, Quanzhi Li, Xiuzhi Wu, Junben Pak J Med Sci Original Article OBJECTIVE: To observe the influence of psychological intervention on pain, immune system and adrenocortical functions of patients receiving lung cancer surgery. METHODS: We selected 124 patients who received surgery for treating stage I or II lung cancer and divided into experimental group and control group. The experimental group received comprehensive psychological intervention while the control group was given conventional nursing intervention. Pain of patients in two groups was evaluated by visual analog scale (VAS). Before and after intervention, CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) and free cortisol level in serum were measured. Moreover, QLQ-C30, a life quality measurement scale developed by European Organization for Research and Treatment of Cancer (EORTC) was used. RESULTS: Compared to control group, VAS of patients in experimental group remarkably decreased before anesthesia, 6 hour, 12 hour 24 hour and 48 hour after surgery (P<0.05), and moreover, OLQ-C30 score and various factor scores (except physical symptoms) in experimental group were much higher (P<0.05). No statistical significant difference was found in immune index between two groups before intervention (P>0.05). Differences of CD3(+) and CD4(+) before and after intervention were both statistically significant (P<0.05), so did free cortisol level (P<0.05). CONCLUSION: Comprehensive psychological intervention can effectively relieve pain, improve immune functions and enhance quality of life for patients suffering from lung cancer surgery. Professional Medical Publications 2016 /pmc/articles/PMC4794516/ /pubmed/27022366 http://dx.doi.org/10.12669/pjms.321.8935 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zhao, Xinying
Cui, Limin
Wang, Wei
Su, Quanzhi
Li, Xiuzhi
Wu, Junben
Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title_full Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title_fullStr Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title_full_unstemmed Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title_short Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
title_sort influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794516/
https://www.ncbi.nlm.nih.gov/pubmed/27022366
http://dx.doi.org/10.12669/pjms.321.8935
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