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Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse
The medullary vagal motor nuclei, the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV), innervate the respiratory and gastrointestinal tracts. We conducted immunohistochemical analysis of expression of the androgen receptor (AR) and estrogen receptor α (ERα), in relation to innervat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794553/ https://www.ncbi.nlm.nih.gov/pubmed/27006520 http://dx.doi.org/10.1267/ahc.15037 |
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author | Mukudai, Shigeyuki Ichi Matsuda, Ken Bando, Hideki Takanami, Keiko Nishio, Takeshi Sugiyama, Yoichiro Hisa, Yasuo Kawata, Mitsuhiro |
author_facet | Mukudai, Shigeyuki Ichi Matsuda, Ken Bando, Hideki Takanami, Keiko Nishio, Takeshi Sugiyama, Yoichiro Hisa, Yasuo Kawata, Mitsuhiro |
author_sort | Mukudai, Shigeyuki |
collection | PubMed |
description | The medullary vagal motor nuclei, the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV), innervate the respiratory and gastrointestinal tracts. We conducted immunohistochemical analysis of expression of the androgen receptor (AR) and estrogen receptor α (ERα), in relation to innervation of the trachea and esophagus via vagal motor nuclei in mice. AR and ERα were expressed in the rostral NA and in part of the DMV. Tracing experiments using cholera toxin B subunit demonstrated that neurons of vagal motor nuclei that innervate the trachea and esophagus express AR and ERα. There was no difference in expression of sex steroid hormone receptors between trachea- and esophagus-innervating neurons. These results suggest that sex steroid hormones may act on vagal motor nuclei via their receptors, thereby regulating functions of the trachea and esophagus. |
format | Online Article Text |
id | pubmed-4794553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY |
record_format | MEDLINE/PubMed |
spelling | pubmed-47945532016-03-22 Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse Mukudai, Shigeyuki Ichi Matsuda, Ken Bando, Hideki Takanami, Keiko Nishio, Takeshi Sugiyama, Yoichiro Hisa, Yasuo Kawata, Mitsuhiro Acta Histochem Cytochem Regular Article The medullary vagal motor nuclei, the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV), innervate the respiratory and gastrointestinal tracts. We conducted immunohistochemical analysis of expression of the androgen receptor (AR) and estrogen receptor α (ERα), in relation to innervation of the trachea and esophagus via vagal motor nuclei in mice. AR and ERα were expressed in the rostral NA and in part of the DMV. Tracing experiments using cholera toxin B subunit demonstrated that neurons of vagal motor nuclei that innervate the trachea and esophagus express AR and ERα. There was no difference in expression of sex steroid hormone receptors between trachea- and esophagus-innervating neurons. These results suggest that sex steroid hormones may act on vagal motor nuclei via their receptors, thereby regulating functions of the trachea and esophagus. JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2016-02-27 2016-02-24 /pmc/articles/PMC4794553/ /pubmed/27006520 http://dx.doi.org/10.1267/ahc.15037 Text en 2016 The Japan Society of Histochemistry and Cytochemistry This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Article Mukudai, Shigeyuki Ichi Matsuda, Ken Bando, Hideki Takanami, Keiko Nishio, Takeshi Sugiyama, Yoichiro Hisa, Yasuo Kawata, Mitsuhiro Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title | Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title_full | Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title_fullStr | Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title_full_unstemmed | Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title_short | Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse |
title_sort | expression of sex steroid hormone receptors in vagal motor neurons innervating the trachea and esophagus in mouse |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794553/ https://www.ncbi.nlm.nih.gov/pubmed/27006520 http://dx.doi.org/10.1267/ahc.15037 |
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