Cargando…

Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422

The hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for virus entry into hepatocytes. A conserved region of E2 encompassing amino acids 412 to 423 (epitope I) and containing Trp420, a residue critical for virus entry, is recognized by several broadly neutralizing antibodies. Peptides emb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sandomenico, Annamaria, Leonardi, Antonio, Berisio, Rita, Sanguigno, Luca, Focà, Giuseppina, Focà, Annalia, Ruggiero, Alessia, Doti, Nunzianna, Muscariello, Livio, Barone, Daniela, Farina, Claudio, Owsianka, Ania, Vitagliano, Luigi, Patel, Arvind H., Ruvo, Menotti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Structure and Assembly
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794675/ https://www.ncbi.nlm.nih.gov/pubmed/26819303 http://dx.doi.org/10.1128/JVI.02397-15

Ejemplares similares

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
por: Focà, Annalia, et al.
Publicado: (2015)

Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions
por: Smaldone, Giovanni, et al.
Publicado: (2021)

Recent Applications of Retro-Inverso Peptides
por: Doti, Nunzianna, et al.
Publicado: (2021)

Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry
por: Sivaccumar, Jwala Priyadarsini, et al.
Publicado: (2021)

Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches
por: Monti, Alessandra, et al.
Publicado: (2023)

Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death
por: Doti, Nunzianna, et al.
Publicado: (2017)

Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis A Virus Particle
por: Bakker, Saskia E., et al.
Publicado: (2014)

Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
por: Crispin, Max, et al.
Publicado: (2014)

Structural Insights into the Human Metapneumovirus Glycoprotein Ectodomain
por: Leyrat, Cedric, et al.
Publicado: (2014)

Impact of Sequence Variation in the UL128 Locus on Production of Human Cytomegalovirus in Fibroblast and Epithelial Cells
por: Murrell, Isa, et al.
Publicado: (2013)

Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins
por: Tanaka, Motoko, et al.
Publicado: (2016)

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region
por: Alhammad, Yousef, et al.
Publicado: (2015)

The Large Tegument Protein pUL36 Is Essential for Formation of the Capsid Vertex-Specific Component at the Capsid-Tegument Interface of Herpes Simplex Virus 1
por: Fan, Wan H., et al.
Publicado: (2014)

A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11
por: Shi, Yuejun, et al.
Publicado: (2016)

Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid
por: York, Royce L., et al.
Publicado: (2016)

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity
por: Ren, Jingshan, et al.
Publicado: (2015)

The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid
por: Kalynych, Sergei, et al.
Publicado: (2016)

Cryo-electron Microscopy Study of the Genome Release of the Dicistrovirus Israeli Acute Bee Paralysis Virus
por: Mullapudi, Edukondalu, et al.
Publicado: (2017)

Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3
por: Mullapudi, Edukondalu, et al.
Publicado: (2016)

Virion Structure of Iflavirus Slow Bee Paralysis Virus at 2.6-Angstrom Resolution
por: Kalynych, Sergei, et al.
Publicado: (2016)

Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein
por: Drokhlyansky, Eugene, et al.
Publicado: (2015)

Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
por: Rujas, Edurne, et al.
Publicado: (2015)

A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2C(ATPase) Causes Conditional Defects in Encapsidation and Uncoating
por: Asare, Emmanuel, et al.
Publicado: (2016)

Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion
por: Mankouri, Jamel, et al.
Publicado: (2016)

Virion Structure of Israeli Acute Bee Paralysis Virus
por: Mullapudi, Edukondalu, et al.
Publicado: (2016)

Structure of Aichi Virus 1 and Its Empty Particle: Clues to Kobuvirus Genome Release Mechanism
por: Sabin, Charles, et al.
Publicado: (2016)

Identification of Essential Genes in the Salmonella Phage SPN3US Reveals Novel Insights into Giant Phage Head Structure and Assembly
por: Thomas, Julie A., et al.
Publicado: (2016)

Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production
por: Chouljenko, Dmitry V., et al.
Publicado: (2016)

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation
por: Parsy, Marie-Laure, et al.
Publicado: (2013)

Crystal Structure of the Human Astrovirus Capsid Protein
por: Toh, Yukimatsu, et al.
Publicado: (2016)

Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon
por: Tian, Xingui, et al.
Publicado: (2018)

The 38K-Mediated Specific Dephosphorylation of the Viral Core Protein P6.9 Plays an Important Role in the Nucleocapsid Assembly of Autographa californica Multiple Nucleopolyhedrovirus
por: Lai, Qingying, et al.
Publicado: (2018)

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope
por: Rissanen, Ilona, et al.
Publicado: (2017)

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α
por: Morger, Damien, et al.
Publicado: (2018)

The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
por: Newman, Joseph, et al.
Publicado: (2018)

A Domain of Herpes Simplex Virus pU(L)33 Required To Release Monomeric Viral Genomes from Cleaved Concatemeric DNA
por: Yang, Kui, et al.
Publicado: (2017)

NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA
por: Zhou, Ting, et al.
Publicado: (2017)

Deep Sequencing of Foot-and-Mouth Disease Virus Reveals RNA Sequences Involved in Genome Packaging
por: Logan, Grace, et al.
Publicado: (2017)

Interaction between a Unique Minor Protein and a Major Capsid Protein of Bluetongue Virus Controls Virus Infectivity
por: Matsuo, Eiko, et al.
Publicado: (2018)

Structural Basis of Nanobodies Targeting the Prototype Norovirus
por: Ruoff, Kerstin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gu79odo228evka9t6nftihagqs