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Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter

CRYAA plays critical functional roles in lens transparency and opacity, and polymorphisms near CRYAA have been associated with age-related cataract (ARC). This study examines polymorphisms in the CRYAA promoter region for association with ARC and elucidates the mechanisms of this association. Three...

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Detalles Bibliográficos
Autores principales:	Ma, Xiaoyin, Jiao, Xiaodong, Ma, Zhiwei, Hejtmancik, J. Fielding
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794711/ https://www.ncbi.nlm.nih.gov/pubmed/26984531 http://dx.doi.org/10.1038/srep23206

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