Cargando…

Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia

Nonalcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide, with genetic, epigenetic, and environmental components. Here, we describe the first example of NAFLD caused by genetic disruption of a mammalian potassium channel subunit. Mice with germline deletion of the KCNE2 pot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Soo Min, Nguyen, Dara, Anand, Marie, Kant, Ritu, Köhncke, Clemens, Lisewski, Ulrike, Roepke, Torsten K., Hu, Zhaoyang, Abbott, Geoffrey W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794722/ https://www.ncbi.nlm.nih.gov/pubmed/26984260 http://dx.doi.org/10.1038/srep23118

Ejemplares similares

KCNE2 and gastric cancer: bench to bedside
por: Abbott, Geoffrey W., et al.
Publicado: (2016)

Targeted Deletion of Kcne2 Causes Gastritis Cystica Profunda and Gastric Neoplasia
por: Roepke, Torsten K., et al.
Publicado: (2010)

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
por: Roepke, Torsten K., et al.
Publicado: (2009)

Targeted Deletion of Kcne2 Impairs HCN Channel Function in Mouse Thalamocortical Circuits
por: Ying, Shui-Wang, et al.
Publicado: (2012)

Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4
por: Abbott, Geoffrey W.
Publicado: (2016)

Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice
por: Hu, Zhaoyang, et al.
Publicado: (2018)

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia
por: Salsbury, Grace, et al.
Publicado: (2014)

KCNE Regulation of K(+) Channel Trafficking – a Sisyphean Task?
por: Kanda, Vikram A., et al.
Publicado: (2012)

Arrhythmogenic KCNE gene variants: current knowledge and future challenges
por: Crump, Shawn M., et al.
Publicado: (2014)

AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2‐dependent sudden cardiac death
por: Hu, Zhaoyang, et al.
Publicado: (2019)

Differential Association between HERG and KCNE1 or KCNE2
por: Um, Sung Yon, et al.
Publicado: (2007)

The KCNE Tango – How KCNE1 Interacts with Kv7.1
por: Wrobel, Eva, et al.
Publicado: (2012)

The focal adhesion protein Testin modulates KCNE2 potassium channel β subunit activity
por: Papanikolaou, Maria, et al.
Publicado: (2021)

Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2
por: Li, Pan, et al.
Publicado: (2014)

Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2
por: Wang, Yuhong, et al.
Publicado: (2012)

KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel
por: Nakajo, Koichi, et al.
Publicado: (2007)

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
por: Barro-Soria, Rene, et al.
Publicado: (2014)

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation
por: Olesen, Morten S, et al.
Publicado: (2012)

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1
por: Erlandsdotter, Lisa-Marie, et al.
Publicado: (2023)

Secondary Structure of a KCNE Cytoplasmic Domain
por: Rocheleau, Jessica M., et al.
Publicado: (2006)

Expression and Localization of Kcne2 in the Vertebrate Retina
por: Lindner, Moritz, et al.
Publicado: (2020)

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting
por: Wrobel, Eva, et al.
Publicado: (2016)

Corrigendum to “Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia” [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1]
por: Salsbury, Grace, et al.
Publicado: (2015)

Structural Investigation of the Transmembrane Domain of KCNE1 in Proteoliposomes
por: Sahu, Indra D., et al.
Publicado: (2014)

A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity
por: Hu, Bin, et al.
Publicado: (2019)

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
por: Kasuya, Go, et al.
Publicado: (2022)

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics
por: Abbott, Geoffrey W., et al.
Publicado: (2021)

Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis
por: Al-Hazza, Adel, et al.
Publicado: (2016)

The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study
por: Hedley, Paula L, et al.
Publicado: (2011)

An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus
por: Sand, Philipp G., et al.
Publicado: (2010)

Structural basis for KCNE3 modulation of potassium recycling in epithelia
por: Kroncke, Brett M., et al.
Publicado: (2016)

The unconventional biogenesis of Kv7.1-KCNE1 complexes
por: Oliveras, Anna, et al.
Publicado: (2020)

Calmodulin-dependent KCNE4 dimerization controls membrane targeting
por: Roig, Sara R., et al.
Publicado: (2021)

Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K(+) conductance in the proximal tubule
por: Neal, A M, et al.
Publicado: (2011)

KCNE1 and KCNE3 β-Subunits Regulate Membrane Surface Expression of Kv12.2 K(+) Channels In Vitro and Form a Tripartite Complex In Vivo
por: Clancy, Sinead M., et al.
Publicado: (2009)

Randomized Controlled Trial Comparing Ferrous Sulfate and Iron Sucrose in Iron Deficiency Anemia in Pregnancy
por: Chauhan, Neha, et al.
Publicado: (2023)

Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes
por: Lussier, Yoann, et al.
Publicado: (2019)

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation
por: Wu, Xiaoan, et al.
Publicado: (2020)

NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria
por: Kant, Ritu, et al.
Publicado: (2013)

KCNE1 Constrains the Voltage Sensor of Kv7.1 K(+) Channels
por: Shamgar, Liora, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_otn0ehtjt93arosbol6vp5qatm