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High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants
BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infections in infants. A small percentage of the infected infants develops a severe infection, while most of these severely ill patients were previously healthy. It remains unclear why these children devel...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794819/ https://www.ncbi.nlm.nih.gov/pubmed/26983753 http://dx.doi.org/10.1186/s12879-016-1454-x |
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author | Vissers, Marloes Ahout, Inge M. van den Kieboom, Corné H. van der Gaast de Jongh, Christa E. Groh, Laszlo Cremers, Amelieke J. de Groot, Ronald de Jonge, Marien I. Ferwerda, Gerben |
author_facet | Vissers, Marloes Ahout, Inge M. van den Kieboom, Corné H. van der Gaast de Jongh, Christa E. Groh, Laszlo Cremers, Amelieke J. de Groot, Ronald de Jonge, Marien I. Ferwerda, Gerben |
author_sort | Vissers, Marloes |
collection | PubMed |
description | BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infections in infants. A small percentage of the infected infants develops a severe infection, while most of these severely ill patients were previously healthy. It remains unclear why these children develop severe RSV infections. In this study, we investigate whether pneumococcal nasopharyngeal carriage patterns correlate with mucosal inflammation and severity of disease. METHODS: In total, 105 infants hospitalized with RSV infection were included and recovery samples were taken from 42 patients. The presence and density of Streptococcus pneumoniae was determined by RT qPCR to study its relation to viral load, inflammation (MMP-9 and IL-6) and severity of RSV disease. RESULTS: We show that pneumococcal presence or absence in the nasopharynx does not correlate with viral load, inflammation or severity of disease. However, when pneumococcus is present in patients, a higher nasopharyngeal pneumococcal density was correlated with a higher RSV load, higher MMP-9 levels and a less severe course of disease. CONCLUSIONS: Our results show correlations between S. pneumoniae density and viral load, inflammation and disease severity, suggesting that pneumococcal density may be an indicator for severity in paediatric RSV disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1454-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4794819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47948192016-03-17 High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants Vissers, Marloes Ahout, Inge M. van den Kieboom, Corné H. van der Gaast de Jongh, Christa E. Groh, Laszlo Cremers, Amelieke J. de Groot, Ronald de Jonge, Marien I. Ferwerda, Gerben BMC Infect Dis Research Article BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infections in infants. A small percentage of the infected infants develops a severe infection, while most of these severely ill patients were previously healthy. It remains unclear why these children develop severe RSV infections. In this study, we investigate whether pneumococcal nasopharyngeal carriage patterns correlate with mucosal inflammation and severity of disease. METHODS: In total, 105 infants hospitalized with RSV infection were included and recovery samples were taken from 42 patients. The presence and density of Streptococcus pneumoniae was determined by RT qPCR to study its relation to viral load, inflammation (MMP-9 and IL-6) and severity of RSV disease. RESULTS: We show that pneumococcal presence or absence in the nasopharynx does not correlate with viral load, inflammation or severity of disease. However, when pneumococcus is present in patients, a higher nasopharyngeal pneumococcal density was correlated with a higher RSV load, higher MMP-9 levels and a less severe course of disease. CONCLUSIONS: Our results show correlations between S. pneumoniae density and viral load, inflammation and disease severity, suggesting that pneumococcal density may be an indicator for severity in paediatric RSV disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1454-x) contains supplementary material, which is available to authorized users. BioMed Central 2016-03-17 /pmc/articles/PMC4794819/ /pubmed/26983753 http://dx.doi.org/10.1186/s12879-016-1454-x Text en © Vissers et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Vissers, Marloes Ahout, Inge M. van den Kieboom, Corné H. van der Gaast de Jongh, Christa E. Groh, Laszlo Cremers, Amelieke J. de Groot, Ronald de Jonge, Marien I. Ferwerda, Gerben High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title | High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title_full | High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title_fullStr | High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title_full_unstemmed | High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title_short | High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
title_sort | high pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794819/ https://www.ncbi.nlm.nih.gov/pubmed/26983753 http://dx.doi.org/10.1186/s12879-016-1454-x |
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