IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

BACKGROUND: Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and acts as a regulator of disc inflammation. The objective of this study was to inv...

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Detalles Bibliográficos
Autores principales: Li, Jing-kun, Nie, Lin, Zhao, Yun-peng, Zhang, Yuan-qiang, Wang, Xiaoqing, Wang, Shuai-shuai, Liu, Yi, Zhao, Hua, Cheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794827/
https://www.ncbi.nlm.nih.gov/pubmed/26988982
http://dx.doi.org/10.1186/s12967-016-0833-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794827/
https://www.ncbi.nlm.nih.gov/pubmed/26988982
http://dx.doi.org/10.1186/s12967-016-0833-9

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