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IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

BACKGROUND: Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and acts as a regulator of disc inflammation. The objective of this study was to inv...

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Detalles Bibliográficos
Autores principales:	Li, Jing-kun, Nie, Lin, Zhao, Yun-peng, Zhang, Yuan-qiang, Wang, Xiaoqing, Wang, Shuai-shuai, Liu, Yi, Zhao, Hua, Cheng, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794827/ https://www.ncbi.nlm.nih.gov/pubmed/26988982 http://dx.doi.org/10.1186/s12967-016-0833-9

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