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Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome

BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with elevated liver enzymes and fatty liver. The purpose of this study was to measure serum liver enzyme levels in patients evaluated by polysomnography (PSG) and the factors associated with liver injury in OSAS patients. MET...

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Autores principales: Li, Jie, Zhang, Yan-Lin, Chen, Rui, Wang, Yi, Xiong, Kang-Ping, Huang, Jun-Ying, Han, Fei, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795259/
https://www.ncbi.nlm.nih.gov/pubmed/26608975
http://dx.doi.org/10.4103/0366-6999.168943
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author Li, Jie
Zhang, Yan-Lin
Chen, Rui
Wang, Yi
Xiong, Kang-Ping
Huang, Jun-Ying
Han, Fei
Liu, Chun-Feng
author_facet Li, Jie
Zhang, Yan-Lin
Chen, Rui
Wang, Yi
Xiong, Kang-Ping
Huang, Jun-Ying
Han, Fei
Liu, Chun-Feng
author_sort Li, Jie
collection PubMed
description BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with elevated liver enzymes and fatty liver. The purpose of this study was to measure serum liver enzyme levels in patients evaluated by polysomnography (PSG) and the factors associated with liver injury in OSAS patients. METHODS: All patients referred to PSG for evaluation of sleep apnea symptoms between June 2011 and November 2014 were included in this study. Demographic data and PSG parameters were recorded. Serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase levels were systematically measured. OSAS patients were divided into mild, moderate, and severe groups according to the apnea-hypopnea index (AHI) values of 5–14 events/h, 15–29 events/h, and ≥30 events/h. RESULTS: A total of 540 patients were enrolled in this study; among these patients, 386 were male. Elevated liver enzymes were present in 42.3% of OSAS patients (32.4% in mild/moderate group; 51.0% in severe group) and 28.1% patients without OSAS. Patients with OSAS had higher body mass index (BMI) (P < 0.01). In the bivariate correlation, the liver enzymes level was negatively correlated with age and the lowest arterial oxygen saturation (SaO(2)), and was positively correlated with BMI, oxygen desaturation index, percent of total time with oxygen saturation level <90% (TS90%), AHI, total cholesterol (TC), and triglyceride (TG). In logistic regression analysis, Age, BMI, TS90%, TC, and TG were included in the regression equation. CONCLUSIONS: Our data suggest that OSAS is a risk factor for elevated liver enzymes. The severity of OSAS is correlated with liver enzyme levels; we hypothesize that hypoxia is one of main causes of liver damage in patients with OSAS.
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spelling pubmed-47952592016-04-04 Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome Li, Jie Zhang, Yan-Lin Chen, Rui Wang, Yi Xiong, Kang-Ping Huang, Jun-Ying Han, Fei Liu, Chun-Feng Chin Med J (Engl) Original Article BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with elevated liver enzymes and fatty liver. The purpose of this study was to measure serum liver enzyme levels in patients evaluated by polysomnography (PSG) and the factors associated with liver injury in OSAS patients. METHODS: All patients referred to PSG for evaluation of sleep apnea symptoms between June 2011 and November 2014 were included in this study. Demographic data and PSG parameters were recorded. Serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase levels were systematically measured. OSAS patients were divided into mild, moderate, and severe groups according to the apnea-hypopnea index (AHI) values of 5–14 events/h, 15–29 events/h, and ≥30 events/h. RESULTS: A total of 540 patients were enrolled in this study; among these patients, 386 were male. Elevated liver enzymes were present in 42.3% of OSAS patients (32.4% in mild/moderate group; 51.0% in severe group) and 28.1% patients without OSAS. Patients with OSAS had higher body mass index (BMI) (P < 0.01). In the bivariate correlation, the liver enzymes level was negatively correlated with age and the lowest arterial oxygen saturation (SaO(2)), and was positively correlated with BMI, oxygen desaturation index, percent of total time with oxygen saturation level <90% (TS90%), AHI, total cholesterol (TC), and triglyceride (TG). In logistic regression analysis, Age, BMI, TS90%, TC, and TG were included in the regression equation. CONCLUSIONS: Our data suggest that OSAS is a risk factor for elevated liver enzymes. The severity of OSAS is correlated with liver enzyme levels; we hypothesize that hypoxia is one of main causes of liver damage in patients with OSAS. Medknow Publications & Media Pvt Ltd 2015-11-20 /pmc/articles/PMC4795259/ /pubmed/26608975 http://dx.doi.org/10.4103/0366-6999.168943 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Li, Jie
Zhang, Yan-Lin
Chen, Rui
Wang, Yi
Xiong, Kang-Ping
Huang, Jun-Ying
Han, Fei
Liu, Chun-Feng
Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title_full Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title_fullStr Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title_full_unstemmed Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title_short Elevated Serum Liver Enzymes in Patients with Obstructive Sleep Apnea-hypopnea Syndrome
title_sort elevated serum liver enzymes in patients with obstructive sleep apnea-hypopnea syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795259/
https://www.ncbi.nlm.nih.gov/pubmed/26608975
http://dx.doi.org/10.4103/0366-6999.168943
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