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Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity
PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795391/ https://www.ncbi.nlm.nih.gov/pubmed/27051486 http://dx.doi.org/10.4103/2008-322X.176892 |
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author | Roohipoor, Ramak Riazi-Esfahani, Mohammad Ebrahimiadib, Nazanin Karkhaneh, Reza Zarei, Mohammad Besharat, Sara Ghassemi, Fariba Ostovaneh, Mohammad Reza |
author_facet | Roohipoor, Ramak Riazi-Esfahani, Mohammad Ebrahimiadib, Nazanin Karkhaneh, Reza Zarei, Mohammad Besharat, Sara Ghassemi, Fariba Ostovaneh, Mohammad Reza |
author_sort | Roohipoor, Ramak |
collection | PubMed |
description | PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope. Zone and stage of ROP, presence of plus disease and need for treatment were recorded. The relationship between the pupillary response to mydriatics, and presence and severity of ROP was evaluated. Logistic regression was used for statistical analysis. RESULTS: According to receiver operating characteristic (ROC) curve analysis, final pupil diameter after mydriatic administration was found the most accurate factor among other factors to recognize ROP zone I from zones II and III (Area under ROC: 0.92 [95%CI: 0.85-0.98]). The best cutoff value for final pupil diameter was 5.6 mm, because it could differentiate involvement of zone I from zones II and III with sensitivity of 80% and specificity of 100%. CONCLUSION: Response of the pupil to mydriatic eye drops may be useful as a less invasive method for rough estimation of ROP in high risk babies who need emergent attention; however, it cannot be considered as a screening test due to its low sensitivity. |
format | Online Article Text |
id | pubmed-4795391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47953912016-04-05 Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity Roohipoor, Ramak Riazi-Esfahani, Mohammad Ebrahimiadib, Nazanin Karkhaneh, Reza Zarei, Mohammad Besharat, Sara Ghassemi, Fariba Ostovaneh, Mohammad Reza J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope. Zone and stage of ROP, presence of plus disease and need for treatment were recorded. The relationship between the pupillary response to mydriatics, and presence and severity of ROP was evaluated. Logistic regression was used for statistical analysis. RESULTS: According to receiver operating characteristic (ROC) curve analysis, final pupil diameter after mydriatic administration was found the most accurate factor among other factors to recognize ROP zone I from zones II and III (Area under ROC: 0.92 [95%CI: 0.85-0.98]). The best cutoff value for final pupil diameter was 5.6 mm, because it could differentiate involvement of zone I from zones II and III with sensitivity of 80% and specificity of 100%. CONCLUSION: Response of the pupil to mydriatic eye drops may be useful as a less invasive method for rough estimation of ROP in high risk babies who need emergent attention; however, it cannot be considered as a screening test due to its low sensitivity. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4795391/ /pubmed/27051486 http://dx.doi.org/10.4103/2008-322X.176892 Text en Copyright: © Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Roohipoor, Ramak Riazi-Esfahani, Mohammad Ebrahimiadib, Nazanin Karkhaneh, Reza Zarei, Mohammad Besharat, Sara Ghassemi, Fariba Ostovaneh, Mohammad Reza Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title | Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title_full | Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title_fullStr | Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title_full_unstemmed | Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title_short | Predictive Value of Pupillary Response to Mydriatic Agents for Diagnosis of Retinopathy of Prematurity |
title_sort | predictive value of pupillary response to mydriatic agents for diagnosis of retinopathy of prematurity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795391/ https://www.ncbi.nlm.nih.gov/pubmed/27051486 http://dx.doi.org/10.4103/2008-322X.176892 |
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