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Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men
OBJECTIVE: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795600/ https://www.ncbi.nlm.nih.gov/pubmed/26986958 http://dx.doi.org/10.1371/journal.pone.0151441 |
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author | Meyer, Haakon E. Støer, Nathalie C. Samuelsen, Sven O. Blomhoff, Rune Robsahm, Trude E. Brustad, Magritt Giovannucci, Edward L. Bjørge, Tone |
author_facet | Meyer, Haakon E. Støer, Nathalie C. Samuelsen, Sven O. Blomhoff, Rune Robsahm, Trude E. Brustad, Magritt Giovannucci, Edward L. Bjørge, Tone |
author_sort | Meyer, Haakon E. |
collection | PubMed |
description | OBJECTIVE: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality. METHODS: Men participating in population based health screenings during 1981–1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. RESULTS: In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05–1.50), s-25(OH)D <50 nmol/l versus s-25(OH)D ≥50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88–1.50) and in the total study population HR = 1.19 (95% CI 1.03–1.38). For cause-specific deaths, we found no significant associations. CONCLUSIONS: In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer. |
format | Online Article Text |
id | pubmed-4795600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47956002016-03-23 Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men Meyer, Haakon E. Støer, Nathalie C. Samuelsen, Sven O. Blomhoff, Rune Robsahm, Trude E. Brustad, Magritt Giovannucci, Edward L. Bjørge, Tone PLoS One Research Article OBJECTIVE: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality. METHODS: Men participating in population based health screenings during 1981–1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. RESULTS: In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05–1.50), s-25(OH)D <50 nmol/l versus s-25(OH)D ≥50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88–1.50) and in the total study population HR = 1.19 (95% CI 1.03–1.38). For cause-specific deaths, we found no significant associations. CONCLUSIONS: In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer. Public Library of Science 2016-03-17 /pmc/articles/PMC4795600/ /pubmed/26986958 http://dx.doi.org/10.1371/journal.pone.0151441 Text en © 2016 Meyer et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Meyer, Haakon E. Støer, Nathalie C. Samuelsen, Sven O. Blomhoff, Rune Robsahm, Trude E. Brustad, Magritt Giovannucci, Edward L. Bjørge, Tone Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title_full | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title_fullStr | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title_full_unstemmed | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title_short | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men |
title_sort | long term association between serum 25-hydroxyvitamin d and mortality in a cohort of 4379 men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795600/ https://www.ncbi.nlm.nih.gov/pubmed/26986958 http://dx.doi.org/10.1371/journal.pone.0151441 |
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