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Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents

OBJECTIVE: To assess the relationship between the degree of waist circumference (WC) and nonalcoholic fatty liver disease (NAFLD) in obese adolescents of both genders, analyzed according to quartiles of WC. METHODS: Cross-sectional study that involved 247 obese adolescents aged 12–19 years. Mean val...

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Autores principales: Clemente, Ana Paula Grotti, Dal Molin, Bárbara, de Carvalho-Ferreira, Joana Pereira, Campos, Raquel Munhoz da Silveira, Ganen, Aline de Piano, Tock, Lian, de Mello, Marco Túlio, Dâmaso, Ana Raimunda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade de Pediatria de São Paulo 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795721/
https://www.ncbi.nlm.nih.gov/pubmed/26830602
http://dx.doi.org/10.1016/j.rppede.2015.10.004
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author Clemente, Ana Paula Grotti
Dal Molin, Bárbara
de Carvalho-Ferreira, Joana Pereira
Campos, Raquel Munhoz da Silveira
Ganen, Aline de Piano
Tock, Lian
de Mello, Marco Túlio
Dâmaso, Ana Raimunda
author_facet Clemente, Ana Paula Grotti
Dal Molin, Bárbara
de Carvalho-Ferreira, Joana Pereira
Campos, Raquel Munhoz da Silveira
Ganen, Aline de Piano
Tock, Lian
de Mello, Marco Túlio
Dâmaso, Ana Raimunda
author_sort Clemente, Ana Paula Grotti
collection PubMed
description OBJECTIVE: To assess the relationship between the degree of waist circumference (WC) and nonalcoholic fatty liver disease (NAFLD) in obese adolescents of both genders, analyzed according to quartiles of WC. METHODS: Cross-sectional study that involved 247 obese adolescents aged 12–19 years. Mean values of the nutritional parameters and serum analyses were compared with the groups using the independent t-test. Pearson correlation coefficient was used to determine the relationship of the parameters studied. Chi-square test for trend was used to determine the relationship between the prevalence of the NAFLD and WC quartile by gender. RESULTS: NAFLD were presented in 60% of the study participants. Obese adolescents in the 3rd and 4th quartiles of WC presented higher prevalence of NAFLD when compared with that in the 1st quartile in both genders. The NAFLD patients had significantly higher values for body weight, BMI (body mass index), BAZ-score (BMI-for-age z-scores), total fat (% and kg), WC, visceral fat, insulin, insulin resistance index (HOMA-IR), aspartate aminotransferase and alanine aminotransferase, when compared with non-NAFLD obese adolescents. CONCLUSIONS: In conclusion, the results presented here suggest that an increase in WC can reliably predict the risk of NAFLD in obese adolescents. This is a low cost and easy-to-use tool that can help in screening in adolescents.
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spelling pubmed-47957212016-04-01 Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents Clemente, Ana Paula Grotti Dal Molin, Bárbara de Carvalho-Ferreira, Joana Pereira Campos, Raquel Munhoz da Silveira Ganen, Aline de Piano Tock, Lian de Mello, Marco Túlio Dâmaso, Ana Raimunda Rev Paul Pediatr Original Articles OBJECTIVE: To assess the relationship between the degree of waist circumference (WC) and nonalcoholic fatty liver disease (NAFLD) in obese adolescents of both genders, analyzed according to quartiles of WC. METHODS: Cross-sectional study that involved 247 obese adolescents aged 12–19 years. Mean values of the nutritional parameters and serum analyses were compared with the groups using the independent t-test. Pearson correlation coefficient was used to determine the relationship of the parameters studied. Chi-square test for trend was used to determine the relationship between the prevalence of the NAFLD and WC quartile by gender. RESULTS: NAFLD were presented in 60% of the study participants. Obese adolescents in the 3rd and 4th quartiles of WC presented higher prevalence of NAFLD when compared with that in the 1st quartile in both genders. The NAFLD patients had significantly higher values for body weight, BMI (body mass index), BAZ-score (BMI-for-age z-scores), total fat (% and kg), WC, visceral fat, insulin, insulin resistance index (HOMA-IR), aspartate aminotransferase and alanine aminotransferase, when compared with non-NAFLD obese adolescents. CONCLUSIONS: In conclusion, the results presented here suggest that an increase in WC can reliably predict the risk of NAFLD in obese adolescents. This is a low cost and easy-to-use tool that can help in screening in adolescents. Sociedade de Pediatria de São Paulo 2016 /pmc/articles/PMC4795721/ /pubmed/26830602 http://dx.doi.org/10.1016/j.rppede.2015.10.004 Text en © 2015 Sociedade de Pediatria de São Paulo. Published by Elsevier Editora Ltda http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Clemente, Ana Paula Grotti
Dal Molin, Bárbara
de Carvalho-Ferreira, Joana Pereira
Campos, Raquel Munhoz da Silveira
Ganen, Aline de Piano
Tock, Lian
de Mello, Marco Túlio
Dâmaso, Ana Raimunda
Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title_full Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title_fullStr Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title_full_unstemmed Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title_short Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
title_sort waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795721/
https://www.ncbi.nlm.nih.gov/pubmed/26830602
http://dx.doi.org/10.1016/j.rppede.2015.10.004
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