Cell Differentiation and Checkpoint

DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation. Among these programs is cell cyc...

Descripción completa

Detalles Bibliográficos
Autores principales: Sancho, Sara Cuesta, Ouchi, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795824/
https://www.ncbi.nlm.nih.gov/pubmed/26998525
_version_ 1782421670992019456
author Sancho, Sara Cuesta
Ouchi, Toru
author_facet Sancho, Sara Cuesta
Ouchi, Toru
author_sort Sancho, Sara Cuesta
collection PubMed
description DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation. Among these programs is cell cycle checkpoint that ensures cell cycle arrest and subsequent repair of the damaged DNA, apoptosis and senescence in various phases of the cell cycle. Moreover, recent studies have established the cell differentiation checkpoint, the other type of the checkpoint that is specifically activated in the course of differentiation. We will discuss the evidences that support the link between DNA damage proteins and C2C12 cell differentiation.
format Online
Article
Text
id pubmed-4795824
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-47958242016-03-17 Cell Differentiation and Checkpoint Sancho, Sara Cuesta Ouchi, Toru Int J Cancer Res Mol Mech Article DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation. Among these programs is cell cycle checkpoint that ensures cell cycle arrest and subsequent repair of the damaged DNA, apoptosis and senescence in various phases of the cell cycle. Moreover, recent studies have established the cell differentiation checkpoint, the other type of the checkpoint that is specifically activated in the course of differentiation. We will discuss the evidences that support the link between DNA damage proteins and C2C12 cell differentiation. 2015-07-02 2015-08 /pmc/articles/PMC4795824/ /pubmed/26998525 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Sancho, Sara Cuesta
Ouchi, Toru
Cell Differentiation and Checkpoint
title Cell Differentiation and Checkpoint
title_full Cell Differentiation and Checkpoint
title_fullStr Cell Differentiation and Checkpoint
title_full_unstemmed Cell Differentiation and Checkpoint
title_short Cell Differentiation and Checkpoint
title_sort cell differentiation and checkpoint
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795824/
https://www.ncbi.nlm.nih.gov/pubmed/26998525
work_keys_str_mv AT sanchosaracuesta celldifferentiationandcheckpoint
AT ouchitoru celldifferentiationandcheckpoint

Ejemplares similares