Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

The secreted disulfide catalyst Quiescin sulfhydryl oxidase-1 (QSOX1) affects extracellular matrix organization and is overexpressed in various adenocarcinomas and associated stroma. Inhibition of extracellular human QSOX1 by a monoclonal antibody decreased tumor cell migration in a cell co-culture...

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Detalles Bibliográficos
Autores principales: Grossman, Iris, Ilani, Tal, Fleishman, Sarel Jacob, Fass, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795942/
https://www.ncbi.nlm.nih.gov/pubmed/26819240
http://dx.doi.org/10.1093/protein/gzv067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795942/
https://www.ncbi.nlm.nih.gov/pubmed/26819240
http://dx.doi.org/10.1093/protein/gzv067

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