The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat

The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690–720 μT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult male Wistar rats. A total of 24 adult Wistar male rats were used, a...

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Autores principales: Shahbazi-Gahrouei, Daryoush, Shiri, Leila, Alaei, Hojjatollah, Naghdi, Naser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Radiation Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795953/
https://www.ncbi.nlm.nih.gov/pubmed/26811259
http://dx.doi.org/10.1093/jrr/rrv093
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author Shahbazi-Gahrouei, Daryoush
Shiri, Leila
Alaei, Hojjatollah
Naghdi, Naser
author_facet Shahbazi-Gahrouei, Daryoush
Shiri, Leila
Alaei, Hojjatollah
Naghdi, Naser
author_sort Shahbazi-Gahrouei, Daryoush
collection PubMed
description The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690–720 μT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult male Wistar rats. A total of 24 adult Wistar male rats were used, and after exposure with an ELF-MF for 15 successive days, all rats in each test were anesthetized with chloral hydrate. Then, they were placed in a stereotaxic frame for surgery and a microdialysis process. Dialysate samples were analyzed to measure the amount of 5-HIAA by high performance liquid chromatography (HPLC) using electrochemical detection. Results showed that ELF-MF exposure for 15 days, 1 h daily, was not effective in altering the level of 5-HIAA. However, ELF-MF exposure for 15 days, 3 h daily, decreased the level of the 5-HIAA in the raphe nucleus. It can be concluded that ELF-MFs affect the serotonergic system and may be used to treat nervous system diseases. This study is an initial step towards helping cure depression using ELF-MFs.
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spelling pubmed-47959532016-03-21 The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat Shahbazi-Gahrouei, Daryoush Shiri, Leila Alaei, Hojjatollah Naghdi, Naser J Radiat Res Radiation Biology The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690–720 μT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult male Wistar rats. A total of 24 adult Wistar male rats were used, and after exposure with an ELF-MF for 15 successive days, all rats in each test were anesthetized with chloral hydrate. Then, they were placed in a stereotaxic frame for surgery and a microdialysis process. Dialysate samples were analyzed to measure the amount of 5-HIAA by high performance liquid chromatography (HPLC) using electrochemical detection. Results showed that ELF-MF exposure for 15 days, 1 h daily, was not effective in altering the level of 5-HIAA. However, ELF-MF exposure for 15 days, 3 h daily, decreased the level of the 5-HIAA in the raphe nucleus. It can be concluded that ELF-MFs affect the serotonergic system and may be used to treat nervous system diseases. This study is an initial step towards helping cure depression using ELF-MFs. Oxford University Press 2016-03 2016-01-24 /pmc/articles/PMC4795953/ /pubmed/26811259 http://dx.doi.org/10.1093/jrr/rrv093 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Radiation Biology
Shahbazi-Gahrouei, Daryoush
Shiri, Leila
Alaei, Hojjatollah
Naghdi, Naser
The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title_full The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title_fullStr The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title_full_unstemmed The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title_short The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat
title_sort effect of continuous elf-mfs on the level of 5-hiaa in the raphe nucleus of the rat
topic Radiation Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795953/
https://www.ncbi.nlm.nih.gov/pubmed/26811259
http://dx.doi.org/10.1093/jrr/rrv093
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