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Inducing amnesia through systemic suppression
Hippocampal damage profoundly disrupts the ability to store new memories of life events. Amnesic windows might also occur in healthy people due to disturbed hippocampal function arising during mental processes that systemically reduce hippocampal activity. Intentionally suppressing memory retrieval...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796356/ https://www.ncbi.nlm.nih.gov/pubmed/26977589 http://dx.doi.org/10.1038/ncomms11003 |
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author | Hulbert, Justin C. Henson, Richard N. Anderson, Michael C. |
author_facet | Hulbert, Justin C. Henson, Richard N. Anderson, Michael C. |
author_sort | Hulbert, Justin C. |
collection | PubMed |
description | Hippocampal damage profoundly disrupts the ability to store new memories of life events. Amnesic windows might also occur in healthy people due to disturbed hippocampal function arising during mental processes that systemically reduce hippocampal activity. Intentionally suppressing memory retrieval (retrieval stopping) reduces hippocampal activity via control mechanisms mediated by the lateral prefrontal cortex. Here we show that when people suppress retrieval given a reminder of an unwanted memory, they are considerably more likely to forget unrelated experiences from periods surrounding suppression. This amnesic shadow follows a dose-response function, becomes more pronounced after practice suppressing retrieval, exhibits characteristics indicating disturbed hippocampal function, and is predicted by reduced hippocampal activity. These findings indicate that stopping retrieval engages a suppression mechanism that broadly compromises hippocampal processes and that hippocampal stabilization processes can be interrupted strategically. Cognitively triggered amnesia constitutes an unrecognized forgetting process that may account for otherwise unexplained memory lapses following trauma. |
format | Online Article Text |
id | pubmed-4796356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47963562016-03-22 Inducing amnesia through systemic suppression Hulbert, Justin C. Henson, Richard N. Anderson, Michael C. Nat Commun Article Hippocampal damage profoundly disrupts the ability to store new memories of life events. Amnesic windows might also occur in healthy people due to disturbed hippocampal function arising during mental processes that systemically reduce hippocampal activity. Intentionally suppressing memory retrieval (retrieval stopping) reduces hippocampal activity via control mechanisms mediated by the lateral prefrontal cortex. Here we show that when people suppress retrieval given a reminder of an unwanted memory, they are considerably more likely to forget unrelated experiences from periods surrounding suppression. This amnesic shadow follows a dose-response function, becomes more pronounced after practice suppressing retrieval, exhibits characteristics indicating disturbed hippocampal function, and is predicted by reduced hippocampal activity. These findings indicate that stopping retrieval engages a suppression mechanism that broadly compromises hippocampal processes and that hippocampal stabilization processes can be interrupted strategically. Cognitively triggered amnesia constitutes an unrecognized forgetting process that may account for otherwise unexplained memory lapses following trauma. Nature Publishing Group 2016-03-15 /pmc/articles/PMC4796356/ /pubmed/26977589 http://dx.doi.org/10.1038/ncomms11003 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hulbert, Justin C. Henson, Richard N. Anderson, Michael C. Inducing amnesia through systemic suppression |
title | Inducing amnesia through systemic suppression |
title_full | Inducing amnesia through systemic suppression |
title_fullStr | Inducing amnesia through systemic suppression |
title_full_unstemmed | Inducing amnesia through systemic suppression |
title_short | Inducing amnesia through systemic suppression |
title_sort | inducing amnesia through systemic suppression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796356/ https://www.ncbi.nlm.nih.gov/pubmed/26977589 http://dx.doi.org/10.1038/ncomms11003 |
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