Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

INTRODUCTION: Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had beneficial effects in several septic animal models, elevated ADM concentration...

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Detalles Bibliográficos
Autores principales: Struck, Joachim, Hein, Frauke, Karasch, Siegmund, Bergmann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796695/
https://www.ncbi.nlm.nih.gov/pubmed/26266791
http://dx.doi.org/10.1186/2197-425X-1-3

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