Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

To establish a new lineage in the human population, avian influenza A viruses (AIV) must overcome the intracellular restriction factor MxA. Partial escape from MxA restriction can be achieved when the viral nucleoprotein (NP) acquires the critical human-adaptive amino acid residues 100I/V, 283P, and...

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Detalles Bibliográficos
Autores principales: Götz, Veronika, Magar, Linda, Dornfeld, Dominik, Giese, Sebastian, Pohlmann, Anne, Höper, Dirk, Kong, Byung-Whi, Jans, David A., Beer, Martin, Haller, Otto, Schwemmle, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796820/
https://www.ncbi.nlm.nih.gov/pubmed/26988202
http://dx.doi.org/10.1038/srep23138

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