The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome

To determine whether a C. elegans bioassay could predict mammalian developmental activity, we selected diverse compounds known and known not to elicit such activity and measured their effect on C. elegans egg viability. 89% of compounds that reduced C. elegans egg viability also had mammalian develo...

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Detalles Bibliográficos
Autores principales: Harlow, Philippa H., Perry, Simon J., Widdison, Stephanie, Daniels, Shannon, Bondo, Eddie, Lamberth, Clemens, Currie, Richard A., Flemming, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796825/
https://www.ncbi.nlm.nih.gov/pubmed/26987796
http://dx.doi.org/10.1038/srep22965

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