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Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin

The interplay between specific integrin-mediated matrix adhesion and directional persistence in cell migration is not well understood. Here, we characterized fibroblast adhesion and migration on the extracellular matrix glycoproteins fibronectin and vitronectin, focusing on the role of α(5)β(1) and...

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Detalles Bibliográficos
Autores principales:	Missirlis, Dimitris, Haraszti, Tamás, Scheele, Catharina v. C., Wiegand, Tina, Diaz, Carolina, Neubauer, Stefanie, Rechenmacher, Florian, Kessler, Horst, Spatz, Joachim P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796868/ https://www.ncbi.nlm.nih.gov/pubmed/26987342 http://dx.doi.org/10.1038/srep23258

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