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ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

ABO blood group system, a well-known genetic risk factor, has clinically been demonstrated to be linked with thrombotic vascular diseases. However, the relationship between ABO blood group and coronary artery disease (CAD) is still controversial. We here performed an updated meta-analysis of the rel...

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Autores principales: Chen, Zhuo, Yang, Sheng-Hua, Xu, Hao, Li, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796869/
https://www.ncbi.nlm.nih.gov/pubmed/26988722
http://dx.doi.org/10.1038/srep23250
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author Chen, Zhuo
Yang, Sheng-Hua
Xu, Hao
Li, Jian-Jun
author_facet Chen, Zhuo
Yang, Sheng-Hua
Xu, Hao
Li, Jian-Jun
author_sort Chen, Zhuo
collection PubMed
description ABO blood group system, a well-known genetic risk factor, has clinically been demonstrated to be linked with thrombotic vascular diseases. However, the relationship between ABO blood group and coronary artery disease (CAD) is still controversial. We here performed an updated meta-analysis of the related studies and tried to elucidate the potential role of ABO blood group as a risk factor for CAD. All detectable case-control and cohort studies comparing the risk of CAD in different ABO blood groups were collected for this analysis through searching PubMed, Embase, and the Cochrane Library. Ultimately, 17 studies covering 225,810 participants were included. The combined results showed that the risk of CAD was significantly higher in blood group A (OR = 1.14, 95% CI = 1.03 to 1.26, p = 0.01) and lower in blood group O (OR = 0.85, 95% CI = 0.78 to 0.94, p = 0.0008). Even when studies merely about myocardial infarction (MI) were removed, the risk of CAD was still significantly higher in blood group A (OR = 1.05, 95% CI = 1.00 to 1.10, p = 0.03) and lower in blood group O (OR = 0.89, 95% CI = 0.85 to 0.93, p < 0.00001). This updated systematic review and meta-analysis indicated that both blood group A and non-O were the risk factors of CAD.
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spelling pubmed-47968692016-03-18 ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis Chen, Zhuo Yang, Sheng-Hua Xu, Hao Li, Jian-Jun Sci Rep Article ABO blood group system, a well-known genetic risk factor, has clinically been demonstrated to be linked with thrombotic vascular diseases. However, the relationship between ABO blood group and coronary artery disease (CAD) is still controversial. We here performed an updated meta-analysis of the related studies and tried to elucidate the potential role of ABO blood group as a risk factor for CAD. All detectable case-control and cohort studies comparing the risk of CAD in different ABO blood groups were collected for this analysis through searching PubMed, Embase, and the Cochrane Library. Ultimately, 17 studies covering 225,810 participants were included. The combined results showed that the risk of CAD was significantly higher in blood group A (OR = 1.14, 95% CI = 1.03 to 1.26, p = 0.01) and lower in blood group O (OR = 0.85, 95% CI = 0.78 to 0.94, p = 0.0008). Even when studies merely about myocardial infarction (MI) were removed, the risk of CAD was still significantly higher in blood group A (OR = 1.05, 95% CI = 1.00 to 1.10, p = 0.03) and lower in blood group O (OR = 0.89, 95% CI = 0.85 to 0.93, p < 0.00001). This updated systematic review and meta-analysis indicated that both blood group A and non-O were the risk factors of CAD. Nature Publishing Group 2016-03-18 /pmc/articles/PMC4796869/ /pubmed/26988722 http://dx.doi.org/10.1038/srep23250 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Zhuo
Yang, Sheng-Hua
Xu, Hao
Li, Jian-Jun
ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title_full ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title_fullStr ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title_full_unstemmed ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title_short ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis
title_sort abo blood group system and the coronary artery disease: an updated systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796869/
https://www.ncbi.nlm.nih.gov/pubmed/26988722
http://dx.doi.org/10.1038/srep23250
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