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Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules

Many biological phenomena involve the binding of proteins to a large object. Because the electrostatic forces that guide binding act over large distances, truncating the size of the system to facilitate computational modeling frequently yields inaccurate results. Our multiscale approach implements a...

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Detalles Bibliográficos
Autores principales: Li, Lin, Alper, Joshua, Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796874/
https://www.ncbi.nlm.nih.gov/pubmed/26988596
http://dx.doi.org/10.1038/srep23249