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Predicting protein thermal stability changes upon point mutations using statistical potentials: Introducing HoTMuSiC
The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first comp...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796876/ https://www.ncbi.nlm.nih.gov/pubmed/26988870 http://dx.doi.org/10.1038/srep23257 |