Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown. Here we show that two mouse strains carrying independent Clec16a mutations developed neurodegenerative disease characterized by motor impairme...

Descripción completa

Detalles Bibliográficos
Autores principales: Redmann, Veronika, Lamb, Christopher A., Hwang, Seungmin, Orchard, Robert C., Kim, Sungsu, Razi, Minoo, Milam, Ashley, Park, Sunmin, Yokoyama, Christine C., Kambal, Amal, Kreamalmeyer, Darren, Bosch, Marie K., Xiao, Maolei, Green, Karen, Kim, Jungsu, Pruett-Miller, Shondra M., Ornitz, David M., Allen, Paul M., Beatty, Wandy L., Schmidt, Robert E., DiAntonio, Aaron, Tooze, Sharon A., Virgin, Herbert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796910/
https://www.ncbi.nlm.nih.gov/pubmed/26987296
http://dx.doi.org/10.1038/srep23326

Ejemplares similares

Ejemplares similares